STRINGSTRING
AFAP1 AFAP1 SH3TC1 SH3TC1 SRC SRC ABLIM2 ABLIM2 GAS7 GAS7 GMDS GMDS FYN FYN RALGAPB RALGAPB ZBED4 ZBED4 LIPML5 LIPML5 NHLRC2 NHLRC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFAP1Actin filament-associated protein 1; Functions as an adapter molecule that links other proteins to the actin cytoskeleton. May function in facilitating interactions between SRC and actin filaments. May modulate changes in actin filament integrity and induce lamellipodia formation. Can cross-link actin filaments into both network and bundle structures. (836 aa)    
Predicted Functional Partners:
SH3TC1
SH3 domain and tetratricopeptide repeats 1.
   
  
 0.815
SRC
Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...]
    
 
 0.810
ABLIM2
Actin binding LIM protein family member 2.
 
    
 0.649
GAS7
Growth arrest specific 7.
   
  
 0.607
GMDS
GDP-mannose 4,6-dehydratase.
      
 0.587
FYN
Tyrosine-protein kinase Fyn; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling.
      
 0.565
RALGAPB
Rap-GAP domain-containing protein.
      
 0.561
ZBED4
Zinc finger BED-type containing 4.
      
 0.532
LIPML5
Lipase; Belongs to the AB hydrolase superfamily. Lipase family.
      
 0.520
NHLRC2
NHL repeat-containing protein 2; Required for normal embryonic development.
      
 0.516
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.