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Ankrd10 Ankrd10 Pms1 Pms1 Cep19 Cep19 Snx25 Snx25 Sugp2 Sugp2 Bves Bves Mogat1 Mogat1 Fcf1 Fcf1 Gm15446 Gm15446 A26c2 A26c2 Gm31371 Gm31371
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Ankrd10Ankyrin repeat domain-containing protein 10. (415 aa)    
Predicted Functional Partners:
Pms1
Postmeiotic segregation increased 1 (S. cerevisiae).
      
 0.711
Cep19
Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes.
      
 0.603
Snx25
Sorting nexin-25; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family.
    
 
 0.582
Sugp2
SURP and G-patch domain-containing protein 2; May play a role in mRNA splicing.
   
  
 0.582
Bves
Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epitheli [...]
      
 0.561
Mogat1
2-acylglycerol O-acyltransferase 1; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine.
    
 
 0.537
Fcf1
rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly; Belongs to the UTP23/FCF1 family. FCF1 subfamily.
   
  
 0.517
Gm15446
Zinc finger protein.
    
 
 0.503
A26c2
ANKRD26-like family C, member 2.
  
 
 
 0.488
Gm31371
Predicted gene, 31371.
  
   
 0.486
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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