node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdhr4 | R3hdm1 | ENSMUSP00000135184 | ENSMUSP00000043103 | Cadherin-related family member 4. | R3H domain-containing 1. | 0.437 |
Copz2 | R3hdm1 | ENSMUSP00000018816 | ENSMUSP00000043103 | Coatomer subunit zeta-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properti [...] | R3H domain-containing 1. | 0.469 |
Mapk7 | R3hdm1 | ENSMUSP00000078087 | ENSMUSP00000043103 | Mitogen-activated protein kinase 7; Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ER [...] | R3H domain-containing 1. | 0.476 |
Nvl | R3hdm1 | ENSMUSP00000027797 | ENSMUSP00000043103 | Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. | R3H domain-containing 1. | 0.569 |
Nvl | Ubxn4 | ENSMUSP00000027797 | ENSMUSP00000027592 | Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. | UBX domain-containing protein 4; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. | 0.464 |
Nvl | Usp34 | ENSMUSP00000027797 | ENSMUSP00000137430 | Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. | Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precurs [...] | 0.421 |
R3hdm1 | Cdhr4 | ENSMUSP00000043103 | ENSMUSP00000135184 | R3H domain-containing 1. | Cadherin-related family member 4. | 0.437 |
R3hdm1 | Copz2 | ENSMUSP00000043103 | ENSMUSP00000018816 | R3H domain-containing 1. | Coatomer subunit zeta-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properti [...] | 0.469 |
R3hdm1 | Mapk7 | ENSMUSP00000043103 | ENSMUSP00000078087 | R3H domain-containing 1. | Mitogen-activated protein kinase 7; Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ER [...] | 0.476 |
R3hdm1 | Nvl | ENSMUSP00000043103 | ENSMUSP00000027797 | R3H domain-containing 1. | Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. | 0.569 |
R3hdm1 | Sbno1 | ENSMUSP00000043103 | ENSMUSP00000142481 | R3H domain-containing 1. | Protein strawberry notch homolog 1; Belongs to the SBNO family. | 0.599 |
R3hdm1 | Trpc5os | ENSMUSP00000043103 | ENSMUSP00000148184 | R3H domain-containing 1. | Putative uncharacterized protein TRPC5OS homolog. | 0.430 |
R3hdm1 | Ubxn4 | ENSMUSP00000043103 | ENSMUSP00000027592 | R3H domain-containing 1. | UBX domain-containing protein 4; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. | 0.417 |
R3hdm1 | Usp34 | ENSMUSP00000043103 | ENSMUSP00000137430 | R3H domain-containing 1. | Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precurs [...] | 0.403 |
Sbno1 | R3hdm1 | ENSMUSP00000142481 | ENSMUSP00000043103 | Protein strawberry notch homolog 1; Belongs to the SBNO family. | R3H domain-containing 1. | 0.599 |
Sbno1 | Usp34 | ENSMUSP00000142481 | ENSMUSP00000137430 | Protein strawberry notch homolog 1; Belongs to the SBNO family. | Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precurs [...] | 0.624 |
Trpc5os | R3hdm1 | ENSMUSP00000148184 | ENSMUSP00000043103 | Putative uncharacterized protein TRPC5OS homolog. | R3H domain-containing 1. | 0.430 |
Ubxn4 | Nvl | ENSMUSP00000027592 | ENSMUSP00000027797 | UBX domain-containing protein 4; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. | Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. | 0.464 |
Ubxn4 | R3hdm1 | ENSMUSP00000027592 | ENSMUSP00000043103 | UBX domain-containing protein 4; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. | R3H domain-containing 1. | 0.417 |
Usp34 | Nvl | ENSMUSP00000137430 | ENSMUSP00000027797 | Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precurs [...] | Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. | 0.421 |