STRINGSTRING
Def8 Def8 Tcf25 Tcf25 Spire2 Spire2 Mthfsd Mthfsd Prss36 Prss36 Spata33 Spata33 Ndel1 Ndel1 Zfp276 Zfp276 Urah Urah Pdcd5 Pdcd5 Dbndd1 Dbndd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Def8Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. (472 aa)    
Predicted Functional Partners:
Tcf25
Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity); Belongs to the TCF25 family.
 
 
  
 0.708
Spire2
Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin [...]
      
 0.657
Mthfsd
Methenyltetrahydrofolate synthase domain-containing protein.
   
  
 0.646
Prss36
Polyserase-2; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg- AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala- Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1 (By similarity); Belongs to the peptidase S1 family.
   
  
 0.629
Spata33
Spermatogenesis-associated protein 33.
    
 
 0.624
Ndel1
Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...]
    
 
 0.582
Zfp276
Zinc finger protein 276; May be involved in transcriptional regulation.
      
 0.571
Urah
5-hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
      
 0.554
Pdcd5
Programmed cell death protein 5; May function in the process of apoptosis; Belongs to the PDCD5 family.
      
 0.532
Dbndd1
Dysbindin domain-containing protein 1.
      
 0.526
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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