node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dbndd1 | Def8 | ENSMUSP00000135524 | ENSMUSP00000104460 | Dysbindin domain-containing protein 1. | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | 0.526 |
Dbndd1 | Spata33 | ENSMUSP00000135524 | ENSMUSP00000058002 | Dysbindin domain-containing protein 1. | Spermatogenesis-associated protein 33. | 0.540 |
Dbndd1 | Spire2 | ENSMUSP00000135524 | ENSMUSP00000010298 | Dysbindin domain-containing protein 1. | Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin [...] | 0.417 |
Dbndd1 | Tcf25 | ENSMUSP00000135524 | ENSMUSP00000056485 | Dysbindin domain-containing protein 1. | Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity); Belongs to the TCF25 family. | 0.448 |
Dbndd1 | Urah | ENSMUSP00000135524 | ENSMUSP00000101665 | Dysbindin domain-containing protein 1. | 5-hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. | 0.604 |
Def8 | Dbndd1 | ENSMUSP00000104460 | ENSMUSP00000135524 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Dysbindin domain-containing protein 1. | 0.526 |
Def8 | Mthfsd | ENSMUSP00000104460 | ENSMUSP00000112116 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Methenyltetrahydrofolate synthase domain-containing protein. | 0.646 |
Def8 | Ndel1 | ENSMUSP00000104460 | ENSMUSP00000018880 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | 0.582 |
Def8 | Pdcd5 | ENSMUSP00000104460 | ENSMUSP00000113761 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Programmed cell death protein 5; May function in the process of apoptosis; Belongs to the PDCD5 family. | 0.532 |
Def8 | Prss36 | ENSMUSP00000104460 | ENSMUSP00000112659 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Polyserase-2; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg- AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala- Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1 (By similarity); Belongs to the peptidase S1 family. | 0.629 |
Def8 | Spata33 | ENSMUSP00000104460 | ENSMUSP00000058002 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Spermatogenesis-associated protein 33. | 0.624 |
Def8 | Spire2 | ENSMUSP00000104460 | ENSMUSP00000010298 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin [...] | 0.657 |
Def8 | Tcf25 | ENSMUSP00000104460 | ENSMUSP00000056485 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity); Belongs to the TCF25 family. | 0.708 |
Def8 | Urah | ENSMUSP00000104460 | ENSMUSP00000101665 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | 5-hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. | 0.554 |
Def8 | Zfp276 | ENSMUSP00000104460 | ENSMUSP00000001092 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Zinc finger protein 276; May be involved in transcriptional regulation. | 0.571 |
Mthfsd | Def8 | ENSMUSP00000112116 | ENSMUSP00000104460 | Methenyltetrahydrofolate synthase domain-containing protein. | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | 0.646 |
Mthfsd | Pdcd5 | ENSMUSP00000112116 | ENSMUSP00000113761 | Methenyltetrahydrofolate synthase domain-containing protein. | Programmed cell death protein 5; May function in the process of apoptosis; Belongs to the PDCD5 family. | 0.486 |
Mthfsd | Tcf25 | ENSMUSP00000112116 | ENSMUSP00000056485 | Methenyltetrahydrofolate synthase domain-containing protein. | Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity); Belongs to the TCF25 family. | 0.485 |
Mthfsd | Urah | ENSMUSP00000112116 | ENSMUSP00000101665 | Methenyltetrahydrofolate synthase domain-containing protein. | 5-hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. | 0.560 |
Ndel1 | Def8 | ENSMUSP00000018880 | ENSMUSP00000104460 | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | 0.582 |