node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankrd16 | Pcmtd2 | ENSMUSP00000052056 | ENSMUSP00000029116 | Ankyrin repeat domain-containing protein 16; Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | 0.575 |
Asb12 | Pcmtd2 | ENSMUSP00000033549 | ENSMUSP00000029116 | Ankyrin repeat and SOCS box protein 12; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | 0.503 |
Asb12 | Wsb2 | ENSMUSP00000033549 | ENSMUSP00000031309 | Ankyrin repeat and SOCS box protein 12; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | WD repeat and SOCS box-containing protein 2; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.476 |
Coro6 | Pcmtd2 | ENSMUSP00000099551 | ENSMUSP00000029116 | Coronin-6. | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | 0.585 |
Coro6 | Vwc2l | ENSMUSP00000099551 | ENSMUSP00000058142 | Coronin-6. | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May promote matrix mineralization , but has been shown to weakly, but significantly inhibit BMP2 and BMP6 activity in a preosteoblastic cell line. | 0.486 |
Eef1akmt1 | Pcmtd2 | ENSMUSP00000022518 | ENSMUSP00000029116 | EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family. | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | 0.536 |
Eid1 | Pcmtd2 | ENSMUSP00000129413 | ENSMUSP00000029116 | EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | 0.508 |
Eid1 | Vwc2l | ENSMUSP00000129413 | ENSMUSP00000058142 | EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May promote matrix mineralization , but has been shown to weakly, but significantly inhibit BMP2 and BMP6 activity in a preosteoblastic cell line. | 0.415 |
Paip2 | Pcmtd2 | ENSMUSP00000158496 | ENSMUSP00000029116 | Polyadenylate-binding protein-interacting protein 2; Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity). Belongs to the PAIP2 family. | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | 0.515 |
Parp8 | Pcmtd2 | ENSMUSP00000022239 | ENSMUSP00000029116 | Protein mono-ADP-ribosyltransferase PARP8; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins. | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | 0.482 |
Pcmtd2 | Ankrd16 | ENSMUSP00000029116 | ENSMUSP00000052056 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | Ankyrin repeat domain-containing protein 16; Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. | 0.575 |
Pcmtd2 | Asb12 | ENSMUSP00000029116 | ENSMUSP00000033549 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | Ankyrin repeat and SOCS box protein 12; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.503 |
Pcmtd2 | Coro6 | ENSMUSP00000029116 | ENSMUSP00000099551 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | Coronin-6. | 0.585 |
Pcmtd2 | Eef1akmt1 | ENSMUSP00000029116 | ENSMUSP00000022518 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family. | 0.536 |
Pcmtd2 | Eid1 | ENSMUSP00000029116 | ENSMUSP00000129413 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. | 0.508 |
Pcmtd2 | Paip2 | ENSMUSP00000029116 | ENSMUSP00000158496 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | Polyadenylate-binding protein-interacting protein 2; Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity). Belongs to the PAIP2 family. | 0.515 |
Pcmtd2 | Parp8 | ENSMUSP00000029116 | ENSMUSP00000022239 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | Protein mono-ADP-ribosyltransferase PARP8; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins. | 0.482 |
Pcmtd2 | Tspoap1 | ENSMUSP00000029116 | ENSMUSP00000048063 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | Peripheral-type benzodiazepine receptor-associated protein 1; Belongs to the RIMBP family. | 0.470 |
Pcmtd2 | Vwc2l | ENSMUSP00000029116 | ENSMUSP00000058142 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May promote matrix mineralization , but has been shown to weakly, but significantly inhibit BMP2 and BMP6 activity in a preosteoblastic cell line. | 0.724 |
Pcmtd2 | Wsb2 | ENSMUSP00000029116 | ENSMUSP00000031309 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. | WD repeat and SOCS box-containing protein 2; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | 0.468 |