node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akip1 | Aurkaip1 | ENSMUSP00000033335 | ENSMUSP00000081114 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation; Belongs to the mitochondrion-specific ribosomal protein mS38 family. | 0.609 |
Akip1 | C2cd2 | ENSMUSP00000033335 | ENSMUSP00000127368 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | C2 domain-containing protein 2. | 0.641 |
Akip1 | Dhrs7c | ENSMUSP00000033335 | ENSMUSP00000130924 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.640 |
Akip1 | Fam120c | ENSMUSP00000033335 | ENSMUSP00000073082 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | Constitutive coactivator of PPAR-gamma-like protein 2. | 0.518 |
Akip1 | Lca5 | ENSMUSP00000033335 | ENSMUSP00000034791 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. | 0.647 |
Akip1 | Rac1 | ENSMUSP00000033335 | ENSMUSP00000098058 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.542 |
Akip1 | Rela | ENSMUSP00000033335 | ENSMUSP00000025867 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kap [...] | 0.573 |
Akip1 | Shisa8 | ENSMUSP00000033335 | ENSMUSP00000137002 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses. | 0.552 |
Akip1 | Trp73 | ENSMUSP00000033335 | ENSMUSP00000101269 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.525 |
Akip1 | Ybey | ENSMUSP00000033335 | ENSMUSP00000045647 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation; Belongs to the endoribonuclease YbeY family. | 0.646 |
Aurkaip1 | Akip1 | ENSMUSP00000081114 | ENSMUSP00000033335 | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation; Belongs to the mitochondrion-specific ribosomal protein mS38 family. | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | 0.609 |
C2cd2 | Akip1 | ENSMUSP00000127368 | ENSMUSP00000033335 | C2 domain-containing protein 2. | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | 0.641 |
C2cd2 | Fam120c | ENSMUSP00000127368 | ENSMUSP00000073082 | C2 domain-containing protein 2. | Constitutive coactivator of PPAR-gamma-like protein 2. | 0.661 |
C2cd2 | Lca5 | ENSMUSP00000127368 | ENSMUSP00000034791 | C2 domain-containing protein 2. | Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. | 0.653 |
C2cd2 | Shisa8 | ENSMUSP00000127368 | ENSMUSP00000137002 | C2 domain-containing protein 2. | Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses. | 0.792 |
C2cd2 | Ybey | ENSMUSP00000127368 | ENSMUSP00000045647 | C2 domain-containing protein 2. | Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation; Belongs to the endoribonuclease YbeY family. | 0.612 |
Dhrs7c | Akip1 | ENSMUSP00000130924 | ENSMUSP00000033335 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | 0.640 |
Fam120c | Akip1 | ENSMUSP00000073082 | ENSMUSP00000033335 | Constitutive coactivator of PPAR-gamma-like protein 2. | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity). | 0.518 |
Fam120c | C2cd2 | ENSMUSP00000073082 | ENSMUSP00000127368 | Constitutive coactivator of PPAR-gamma-like protein 2. | C2 domain-containing protein 2. | 0.661 |
Fam120c | Lca5 | ENSMUSP00000073082 | ENSMUSP00000034791 | Constitutive coactivator of PPAR-gamma-like protein 2. | Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia. | 0.492 |