node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankfn1 | Mmd | ENSMUSP00000049776 | ENSMUSP00000004050 | Ankyrin-repeat and fibronectin type III domain-containing 1. | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.447 |
Csf1r | Mmd | ENSMUSP00000110923 | ENSMUSP00000004050 | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.405 |
Hilpda | Mmd | ENSMUSP00000060791 | ENSMUSP00000004050 | Hypoxia-inducible lipid droplet-associated protein; Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation (By similarity). | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.481 |
Hmgb3 | Mmd | ENSMUSP00000110229 | ENSMUSP00000004050 | High mobility group protein B3; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cel [...] | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.405 |
Mmd | Ankfn1 | ENSMUSP00000004050 | ENSMUSP00000049776 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | Ankyrin-repeat and fibronectin type III domain-containing 1. | 0.447 |
Mmd | Csf1r | ENSMUSP00000004050 | ENSMUSP00000110923 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] | 0.405 |
Mmd | Hilpda | ENSMUSP00000004050 | ENSMUSP00000060791 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | Hypoxia-inducible lipid droplet-associated protein; Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation (By similarity). | 0.481 |
Mmd | Hmgb3 | ENSMUSP00000004050 | ENSMUSP00000110229 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | High mobility group protein B3; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cel [...] | 0.405 |
Mmd | Nxpe2 | ENSMUSP00000004050 | ENSMUSP00000034527 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | NXPE family member 2. | 0.475 |
Mmd | Paqr3 | ENSMUSP00000004050 | ENSMUSP00000108593 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Belongs to the ADIPOR family. | 0.661 |
Mmd | Paqr4 | ENSMUSP00000004050 | ENSMUSP00000024702 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | Progestin and adipoQ receptor family member 4. | 0.645 |
Mmd | Paqr5 | ENSMUSP00000004050 | ENSMUSP00000034817 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | Membrane progestin receptor gamma; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. | 0.460 |
Mmd | Stxbp4 | ENSMUSP00000004050 | ENSMUSP00000116191 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | Syntaxin-binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. | 0.436 |
Mmd | Trmt10a | ENSMUSP00000004050 | ENSMUSP00000125749 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | tRNA methyltransferase 10 homolog A; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family. | 0.477 |
Nxpe2 | Mmd | ENSMUSP00000034527 | ENSMUSP00000004050 | NXPE family member 2. | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.475 |
Paqr3 | Mmd | ENSMUSP00000108593 | ENSMUSP00000004050 | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Belongs to the ADIPOR family. | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.661 |
Paqr4 | Mmd | ENSMUSP00000024702 | ENSMUSP00000004050 | Progestin and adipoQ receptor family member 4. | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.645 |
Paqr5 | Mmd | ENSMUSP00000034817 | ENSMUSP00000004050 | Membrane progestin receptor gamma; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.460 |
Stxbp4 | Mmd | ENSMUSP00000116191 | ENSMUSP00000004050 | Syntaxin-binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.436 |
Trmt10a | Mmd | ENSMUSP00000125749 | ENSMUSP00000004050 | tRNA methyltransferase 10 homolog A; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family. | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Belongs to the ADIPOR family. | 0.477 |