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Rnf149 Rnf149 Zfp319 Zfp319 Cdadc1 Cdadc1 Arl11 Arl11 Tagap1 Tagap1 Fam151b Fam151b Zfp738 Zfp738 Ube2z Ube2z Lrrc57 Lrrc57 B3gnt4 B3gnt4 Josd1 Josd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Rnf149E3 ubiquitin-protein ligase RNF149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. (394 aa)    
Predicted Functional Partners:
Zfp319
Zinc finger protein 319; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.564
Cdadc1
Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis.
   
  
 0.533
Arl11
ADP-ribosylation factor-like protein 11; May play a role in apoptosis. May act as a tumor suppressor (By similarity).
      
 0.519
Tagap1
T-cell activation GTPase-activating protein 1.
   
  
 0.497
Fam151b
Family with sequence similarity 151, member B.
   
  
 0.489
Zfp738
Zinc finger protein 738.
      
 0.489
Ube2z
Ubiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.462
Lrrc57
Leucine-rich repeat-containing protein 57.
    
 
 0.420
B3gnt4
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides; Belongs to the glycosyltransferase 31 family.
      
 0.418
Josd1
Josephin-1; Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly- ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).
   
 
 0.414
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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