STRINGSTRING
Ccdc34 Ccdc34 Fam216a Fam216a Lgr4 Lgr4 Ccdc150 Ccdc150 Ccdc77 Ccdc77 Nemp1 Nemp1 Ribc2 Ribc2 Gstcd Gstcd Lin7c Lin7c Depdc1b Depdc1b Ccdc106 Ccdc106
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ccdc34Coiled-coil domain-containing protein 34. (367 aa)    
Predicted Functional Partners:
Fam216a
Protein FAM216A; Belongs to the FAM216 family.
   
  
 0.699
Lgr4
Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...]
 
  
 
 0.687
Ccdc150
Coiled-coil domain-containing protein 150.
      
 0.665
Ccdc77
Coiled-coil domain-containing protein 77.
   
  
 0.651
Nemp1
Nuclear envelope integral membrane protein 1.
   
  
 0.615
Ribc2
RIB43A-like with coiled-coils protein 2; Belongs to the RIB43A family.
   
 
 0.604
Gstcd
Glutathione S-transferase C-terminal domain-containing protein; Belongs to the GSTCD family.
   
 
 0.604
Lin7c
Protein lin-7 homolog C; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may funct [...]
   
  
 0.599
Depdc1b
DEP domain-containing protein 1B.
   
  
 0.599
Ccdc106
Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
      
 0.590
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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