STRINGSTRING
ML0192 ML0192 ML0193 ML0193 ML2137 ML2137 ML0857 ML0857 ML0603 ML0603 ML0703 ML0703 ML0921 ML0921 ML2410 ML2410 ML1439 ML1439 ML1677 ML1677 ML2473 ML2473
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0192Putative membrane protein; Similar to M. tuberculosis Rv1002c, probable membrane protein, TR:O05586 (EMBL:AL123456) (503 aa); Fasta score E(): 0, 80.4% identity in 510 aa overlap. Also similar to Streptomyces coelicolor SCE87.05, putative integral membrane protein, TR:Q9RKD3 (EMBL:AL132674) (591 aa); Fasta score E(): 0, 36.7% identity in 531 aa overlap. Contains hydrophobic, possible membrane-spanning regions. (510 aa)    
Predicted Functional Partners:
ML0193
Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
       0.749
ML2137
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 27.4 kda protein rv0883c SW:Y883_MYCTU (Q10545) fasta scores: E(): 0, 79.4% in 253 aa, and to Streptomyces coelicolor hypothetical 39.0 kda protein TR:O50529 (EMBL:AL009204) fasta scores: E(): 2.2e-19, 36.0% in 247 aa.
  
     0.659
ML0857
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 26.9 kDa protein Rv2219 or MTCY190.30 SW:YM19_MYCTU (Q10405) (250 aa) fasta scores: E(): 0, 80.8% id in 250 aa. Similar to Streptomyces coelicolor putative integral membrane protein SC3H12.04 TR:CAB90843 (EMBL:AL355740) (234 aa) fasta scores: E(): 1.2e-26, 39.6% id in 230 aa and to Streptomyces coelicolor putative integral membrane protein SC5F7.05 TR:Q9S2P0 (EMBL:AL096872) (234 aa) fasta scores: E(): 1.2e-26, 39.6% id in 230 aa. Previously sequenced as TR:O32963 (EMBL:Z98741). Contains hydrophobic, possible [...]
  
     0.654
ML0603
Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
  
     0.567
ML0703
Similar to M. tuberculosis Rv3311, conserved hypothetical protein, TR:O53362 (EMBL:AL123456) (420 aa); Fasta score E(): 0, 77.5% identity in 423 aa overlap.
  
     0.565
ML0921
Possible membrane protein; Similar to several proteins of unknown function e.g. Mycobacterium tuberculosis TR:O06230 (EMBL:Z95388) (96 aa); Fasta score E(): 2.8e-32, 88.5% identity in 96 aa overlap and Streptomyces coelicolor TR:Q9S2X3 (EMBL:AL109663) (94 aa); Fasta score E(): 2.9e-12, 40.7% identity in 86 aa overlap. Contains possible membrane spanning hydrophobic domains.
  
     0.539
ML2410
Conserved membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv0528 TR:O06394 (EMBL:Z95558) (529 aa) fasta scores: E(): 0, 80.9% id in 530 aa. Contains multiple possible membrane spanning hydrophobic domains.
  
     0.533
ML1439
Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.
  
     0.523
ML1677
Possible secreted protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2980 TR:P95115 (EMBL:Z83018) (181 aa); Fasta score E(): 0, 67.2% identity in 177 aa overlap. Contains a possible N-terminal signal sequence.
  
     0.510
ML2473
Similar to Mycobacterium tuberculosis hypothetical protein Rv3753c TR:O69720 (EMBL:AL022121) fasta scores: E(): 0, 88.3% id in 163 aa.
  
     0.499
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.