STRINGSTRING
fabG1 fabG1 inhA inhA kasA kasA kasB kasB fabD fabD fas fas hemZ hemZ rpoB rpoB tlyA tlyA embB embB ML1808 ML1808
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fabG13-oxoacyl-[ACP] reductase (aka MabA); Similar to M. tuberculosis fabG Rv1483 SW:FABG_MYCTU (Q48930) (247 aa); Fasta score E(): 0, 68.6% identity in 245 aa overlap, and to many others e.g. Escherichia coli fabG 3-oxoacyl-[acyl-carrier protein] reductase SW:FABG_ECOLI (P25716) (244 aa); Fasta score E(): 0, 47.3% identity in 241 aa overlap. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature; Simil [...] (253 aa)    
Predicted Functional Partners:
inhA
enoyl-[ACP] reductase; Similar to M. tuberculosis inhA Rv1484 SW:INHA_MYCTU (P46533) (269 aa); Fasta score E(): 0, 90.3% identity in 269 aa overlap, and to many others e.g. Escherichia coli enoyl-[acyl-carrier-protein] reductase [NADH] SW:FABI_ECOLI (P29132) (261 aa); Fasta score E(): 1.2e-17, 33.2% identity in 268 aa overlap; Similar to and ML1807.
 
  
 0.976
kasA
3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 
 0.928
kasB
3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 
 0.919
fabD
Malonyl CoA-[ACP] transacylase; Similar to many malonyl CoA-acyl carrier protein transacylases (EC 2.3.1.39) involved in fatty acid biosynthesis, including: Salmonella typhimurium SW:FABD_SALTY (O85140) (308 aa); Fasta score E(): 1.6e-19, 32.7% identity in 303 aa overlap and Mycobacterium tuberculosis SW:FABD_MYCTU (Q10501) (302 aa); Fasta score E(): 0, 82.2% identity in 304 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain.
 
 
 0.899
fas
Fatty acid synthase; Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); Fasta score E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 [...]
  
 0.890
hemZ
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
     
 0.818
rpoB
[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.816
tlyA
Cytotoxin/hemolysin; Highly similar to several proposed hemolysins including: Mycobacterium ulcerans TlyA TR:CAB83047 (EMBL:AJ271681) (281 aa); Fasta score E(): 0, 81.0% identity in 268 aa overlap, Treponema hyodysenteriae hemolysin A SW:HLYA_TREHY (Q06803) (240 aa); Fasta score E(): 2.3e-23, 34.9% identity in 238 aa overlap and Mycobacterium tuberculosis TR:Q50760 (EMBL:X98295) (268 aa); Fasta score E(): 0, 78.4% identity in 268 aa overlap. Contains possible membrane spanning hydrophobic domains.
      
 0.783
embB
Putative arabinosyl transferase; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family.
      
 0.782
ML1808
Possible membrane protein; Similar to M. tuberculosis Rv1481 SW:YE81_MYCTU (P71762) (335 aa); Fasta score E(): 0, 91.0% identity in 335 aa overlap. Contains Pfam match to entry PF00092 vwa, von Willebrand factor type A domain; Similar to and ML0701.
       0.759
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.