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DIP1993 DIP1993 panB panB panC panC coaA coaA DIP0950 DIP0950 dfp dfp DIP1994 DIP1994 DIP1999 DIP1999 folK folK DIP1998 DIP1998 DIP1995 DIP1995
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
DIP1993Conserved hypothetical protein; C-terminus is similar to the C-terminal region of Lotus japonicus pantoate--beta-alanine ligase precursor PanC SW:PANC_LOTJA (O24035) (307 aa) fasta scores: E(): 4.4e-07, 28.11% id in 217 aa. Similar to the Mycobacterium tuberculosis pantoate--beta-alanine ligase Rv3602c SW:PANC_MYCTU (O06280) (309 aa) fasta scores: E(): 4.7e-19, 38.62% id in 277 aa; Belongs to the pantothenate synthetase family. (259 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
 
  
 0.959
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
  
 
0.928
coaA
Pantothenate kinase; Similar to Escherichia coli pantothenate kinase CoaA or Rts or PanK or B3974 or Z5545 or ECS4901 SW:COAA_ECOLI (P15044) (316 aa) fasta scores: E(): 7.4e-62, 52.27% id in 308 aa, and to Mycobacterium tuberculosis pantothenate kinase CoaA or Rv1092c or MT1124 or MTV017.45C SW:COAA_MYCTU (O53440) (312 aa) fasta scores: E(): 1e-76, 64.42% id in 312 aa.
     
 0.920
DIP0950
Putative oxidoreductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.917
dfp
DNA/pantothenate metabolism flavoprotein homolog; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
 
 0.850
DIP1994
Hypothetical protein; Poor database matches. N-terminus is similar to the C-terminal region of Pseudomonas aeruginosa malonate decarboxylase alpha subunit PA0208 TR:Q9I6T0 (EMBL:AE004459) (554 aa) fasta scores: E(): 3.7, 32.31% id in 164 aa.
     
 0.831
DIP1999
Putative dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
  
 0.794
folK
Putative 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK SW:HPPK_ECOLI (P26281) (158 aa) fasta scores: E(): 1.1e-11, 36.36% id in 154 aa, and to Mycobacterium tuberculosis 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Rv3606c SW:HPPK_MYCTU (O06276) (188 aa) fasta scores: E(): 6e-23, 48.93% id in 141 aa.
     
 0.792
DIP1998
Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
     
 0.791
DIP1995
Putative membrane protein; Weakly similar to the N-terminal regions of Mycobacterium leprae putative membrane protein ML0228 TR:O69526 (EMBL:AL023093) (432 aa) fasta scores: E(): 0.025, 25.15% id in 318 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3709 TR:AAK48067 (EMBL:AE007170) (397 aa) fasta scores: E(): 0.071, 23.51% id in 336 aa.
       0.784
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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