STRINGSTRING
ML0051 ML0051 ML0050 ML0050 ML0049 ML0049 ML0405 ML0405 ML0052 ML0052 ML0053 ML0053 ML0054 ML0054 ML0055 ML0055 ML0393 ML0393 ML0810 ML0810 ML0048 ML0048
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0051Similar to PPE-family proteins from M. tuberculosis e.g. Rv3873, PPE-family protein, TR:O69738 (EMBL:AL123456) (368 aa); Fasta score E(): 6.1e-32, 46.2% identity in 288 aa overlap. Lacks the PPE motif at the N-terminus. Previously sequenced as TR:O33085 (EMBL:Y14967) (302 aa); Fasta score E(): 0, 100.0% identity in 302 aa overlap. Contains Pfam match to entry PF00823 PPE, PPE family; N-terminus is similar to the N-termini of ML0539, ML1828 and ML1991. (302 aa)    
Predicted Functional Partners:
ML0050
Possible secreted protein; A secreted protein that might play a role in virulence. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA.
     
 0.911
ML0049
Possible secreted protein; A secreted protein that might play a role in virulence.
     
 0.813
ML0405
Similar to M. tuberculosis Rv3616c, conserved hypothetical protein, TR:O06267 (EMBL:AL123456) (392 aa); Fasta score E(): 0, 62.7% identity in 394 aa overlap and to Rv3864, hypothetical protein, TR:P96213 (EMBL:AL123456) (402 aa); Fasta score E(): 2.1e-15, 31.0% identity in 410 aa overlap. Previously sequenced as TR:Q49722 (EMBL:U00015) (394 aa); Fasta score E(): 0, 100.0% identity in 394 aa overlap.
  
  
 0.773
ML0052
Conserved hypothetical protein; Similar to putative ATP/GTP-binding proteins from M. tuberculosis and Streptomyces coelicolor e.g. M. tuberculosis Rv3871, hypothetical protein, TR:O69736 (EMBL:AL123456) (591 aa); Fasta score E(): 0, 80.9% identity in 596 aa overlap. In several of these cases this protein is similar to the C-terminal half of a larger protein, while the upstream ML0053 is similar to the corresponding N-terminal half e.g. M. tuberculosis Rv3447c, unknown membrane protein, TR:O06264 (EMBL:AL123456) (1236 aa); Fasta score E(): 0, 35.2% identity in 588 aa overlap and Strepto [...]
     
 0.649
ML0053
Similar to putative ATP/GTP-binding proteins from M. tuberculosis and Streptomyces coelicolor e.g. M. tuberculosis Rv3870, hypothetical protein, TR:O69735 (EMBL:AL123456) (747 aa); Fasta score E(): 0, 85.4% identity in 746 aa overlap. In several of these cases this protein is similar to the N-terminal half of a larger protein, while the downstream ML0052 is similar to the corresponding C-terminal half e.g. M.tuberculosis Rv3447c, unknown membrane protein, TR:O06264 (EMBL:AL123456) (1236 aa); Fasta score E(): 0, 37.2% identity in 732 aa overlap and Streptomyces coelicolor SC3C3.20C, ATP [...]
       0.645
ML0054
Putative membrane protein; Similar to several M. tuberculosis hypothetical proteins e.g. Rv3869, conserved hypothetical protein, TR:O69734 (EMBL:AL123456) (480 aa); Fasta score E(): 0, 75.7% identity in 478 aa overlap. Previously sequenced as TR:O33088 (EMBL:Y14967) (481 aa); Fasta score E(): 0, 100.0% identity in 481 aa overlap. Contains hydrophobic, possible membrane-spanning region near the N-terminus; Similar to ML1544 and ML2536.
       0.645
ML0055
Conserved hypothetical protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity).
  
  
 0.607
ML0393
Putative hydrolase; Similar to M. tuberculosis Rv3400, hypothetical protein, SW:YY00_MYCTU (Q50725) (262 aa); Fasta score E(): 0, 74.4% identity in 262 aa overlap. Previously sequenced as SW:YY00_MYCLE (Q49741) (261 aa); Fasta score E(): 0, 100.0% identity in 261 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase.
      
 0.487
ML0810
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 42.5 kDa protein Rv3212 or MTCY07D11.14c (407 aa) TR:O05854 (EMBL:Z95120) fasta scores: E(): 0, 79.9% id in 407 aa. Contains hydrophobic, possible membrane-spanning region.
      
 0.471
ML0048
Conserved hypothetical protein; Has a proline-rich N-terminus. Similar to several proteins from M. tuberculosis, some of which also contain proline-rich regions e.g. M.tuberculosis Rv3876, hypothetical protein, TR:O69740 (EMBL:AL123456) (666 aa); Fasta score E(): 0, 50.7% identity in 672 aa overlap, and Rv0530, hypothetical protein, TR:O06396 (EMBL:AL123456) (405 aa); Fasta score E(): 1.3e-19, 30.5% identity in 417 aa overlap. Similar to the C-terminal half of Streptomyces coelicolor SC3C3.03C, hypothetical protein, TR:O86637 (EMBL:AL031231) (1083 aa); Fasta score E(): 5.9e-27, 31.6% i [...]
  
  
 0.464
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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