Dl3525W protein (Arabidopsis thaliana) - STRING interaction network

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Score

Dl3525W

Fanconi anemia group D2 protein. (1484 aa)

Predicted Functional Partners:

K20J1.8

0.999

MPA24.9

0.998

FAN1

0.973

BRCA2B

0.945

BRCA2A

0.944

T17C22.4

0.930

UBC37

0.906

ATR

0.897

AT5G12460.1

0.896

T16L4.70

0.893

Your Current Organism:

Arabidopsis thaliana

NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AT5G12460.1	BRCA2A	Q1PDX3	Q7Y1C5	Fringe-like protein (DUF604).	Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.	0.481
AT5G12460.1	BRCA2B	Q1PDX3	Q7Y1C4	Fringe-like protein (DUF604).	Protein BREAST CANCER SUSCEPTIBILITY 2 homolog B; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.	0.470
AT5G12460.1	Dl3525W	Q1PDX3	F4JIJ1	Fringe-like protein (DUF604).	Fanconi anemia group D2 protein.	0.896
AT5G12460.1	FAN1	Q1PDX3	Q5XVJ4	Fringe-like protein (DUF604).	Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICLs). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity). May act upstream of the helicase RECQL4A and the ATPase RAD5A, which is involved in error-free post-replicative repair. Functions independently of MUS81 pathway, but in a similar pathway with RECQ4A, RAD5A and MFH1 in ICL repair.	0.576
AT5G12460.1	K20J1.8	Q1PDX3	F4K4R1	Fringe-like protein (DUF604).	Fanconi anemia group I-like protein.	0.900
AT5G12460.1	MPA24.9	Q1PDX3	B9DHA4	Fringe-like protein (DUF604).	Zinc ion binding protein.	0.719
AT5G12460.1	T16L4.70	Q1PDX3	Q9SU89	Fringe-like protein (DUF604).	Fanconi anemia group E protein FANCE protein.	0.784
AT5G12460.1	T17C22.4	Q1PDX3	Q8S8G1	Fringe-like protein (DUF604).	ARM repeat superfamily protein.	0.757
AT5G12460.1	UBC37	Q1PDX3	Q941B6	Fringe-like protein (DUF604).	Probable ubiquitin-conjugating enzyme E2 37; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.	0.666
ATR	BRCA2A	Q9FKS4	Q7Y1C5	Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2- arrest response to double-strand breaks. May also be involved in the meiosis proc [...]	Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.	0.543
ATR	BRCA2B	Q9FKS4	Q7Y1C4	Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2- arrest response to double-strand breaks. May also be involved in the meiosis proc [...]	Protein BREAST CANCER SUSCEPTIBILITY 2 homolog B; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.	0.765
ATR	Dl3525W	Q9FKS4	F4JIJ1	Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2- arrest response to double-strand breaks. May also be involved in the meiosis proc [...]	Fanconi anemia group D2 protein.	0.897
ATR	FAN1	Q9FKS4	Q5XVJ4	Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2- arrest response to double-strand breaks. May also be involved in the meiosis proc [...]	Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICLs). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity). May act upstream of the helicase RECQL4A and the ATPase RAD5A, which is involved in error-free post-replicative repair. Functions independently of MUS81 pathway, but in a similar pathway with RECQ4A, RAD5A and MFH1 in ICL repair.	0.689
ATR	K20J1.8	Q9FKS4	F4K4R1	Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2- arrest response to double-strand breaks. May also be involved in the meiosis proc [...]	Fanconi anemia group I-like protein.	0.824
ATR	MPA24.9	Q9FKS4	B9DHA4	Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2- arrest response to double-strand breaks. May also be involved in the meiosis proc [...]	Zinc ion binding protein.	0.754
ATR	UBC37	Q9FKS4	Q941B6	Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2- arrest response to double-strand breaks. May also be involved in the meiosis proc [...]	Probable ubiquitin-conjugating enzyme E2 37; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.	0.427
BRCA2A	AT5G12460.1	Q7Y1C5	Q1PDX3	Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.	Fringe-like protein (DUF604).	0.481
BRCA2A	ATR	Q7Y1C5	Q9FKS4	Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.	Serine/threonine-protein kinase ATR; Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2- arrest response to double-strand breaks. May also be involved in the meiosis proc [...]	0.543
BRCA2A	BRCA2B	Q7Y1C5	Q7Y1C4	Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.	Protein BREAST CANCER SUSCEPTIBILITY 2 homolog B; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.	0.906
BRCA2A	Dl3525W	Q7Y1C5	F4JIJ1	Protein BREAST CANCER SUSCEPTIBILITY 2 homolog A; Involved in double-strand break repair and/or homologous recombination by mediating RAD51- and DMC1-facilitated DNA repair. Plays an essential role in both somatic and meiotic homologous recombination. Is crucial for the formation of RAD51 and DMC1 foci during male meiotic homologous recombination in prophase I.	Fanconi anemia group D2 protein.	0.944