STRINGSTRING
POL2A POL2A DPB2 DPB2 POLA POLA NF-YB11 NF-YB11 POLA2 POLA2 POLD2 POLD2 EMB2813 EMB2813 POLA3 POLA3 cdc45 cdc45 MCM5 MCM5 MCM3 MCM3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
POL2ADNA polymerase epsilon catalytic subunit A; DNA polymerase II, which participates in chromosomal DNA replication. Required for the timing and determination of cell fate during plant embryogenesis and root pole development, by promoting cell cycle and cell type patterning. Necessary for proper shoot (SAM) and root apical meristem (RAM) functions. Involved in maintaining epigenetic states, controlling hypersensitive response (HR), and mediating abscisic acid (ABA) signaling. Required for flowering repression through a mechanism involving epigenetic gene silencing. May participate in proc [...] (2161 aa)    
Predicted Functional Partners:
DPB2
DNA polymerase epsilon subunit B; As accessory component of DNA polymerase II participates in chromosomal DNA replication. Required for the timing and determination of cell fate during plant embryogenesis and root pole development, by promoting cell cycle and cell type patterning. Necessary for proper shoot (SAM) and root apical meristem (RAM) functions (By similarity). Is essential to promote the first divisions of the zygote.
   
 0.999
POLA
DNA polymerase alpha catalytic subunit; Polymerase alpha in a complex with DNA primase is a replicative polymerase; Belongs to the DNA polymerase type-B family.
   
 0.999
NF-YB11
Putative CCAAT-binding transcription factor subunit.
   
 0.999
POLA2
DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
   
 0.997
POLD2
DNA polymerase delta small subunit; The function of the small subunit is not yet clear.
   
 0.997
EMB2813
Probable DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.
   
 0.997
POLA3
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
   
 0.996
cdc45
CDC45 (Cell division cycle 45)-like protein.
   
 0.993
MCM5
DNA replication licensing factor MCM5; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.
   
 0.992
MCM3
DNA replication licensing factor MCM3; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.
   
 0.992
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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