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mnmC mnmC soxA soxA trmU trmU gidA gidA rnpA rnpA trmL trmL BPSL0710 BPSL0710 soxD soxD BPSS1719 BPSS1719 rlmN rlmN dadX dadX
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mnmCConserved hypothetical protein; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. (684 aa)    
Predicted Functional Partners:
soxA
Similar to Corynebacterium sp. sarcosine oxidase alpha subunit SoxA SWALL:SOXA_CORS1 (SWALL:Q46337) (967 aa) fasta scores: E(): 2.3e-145, 46.45% id in 1014 aa, and to Ralstonia solanacearum probable sarcosine oxidase SoxA2 or rsc1103 or rs04054 SWALL:Q8Y0E1 (EMBL:AL646062) (1003 aa) fasta scores: E(): 0, 86.14% id in 1003 aa, and to Pseudomonas aeruginosa sarcosine oxidase alpha subunit SoxA or pa5418 SWALL:Q9HTE6 (EMBL:AE004954) (1005 aa) fasta scores: E(): 1.3e-211, 57.46% id in 1011 aa; Belongs to the GcvT family.
  
 
 0.892
trmU
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
  
 
 0.715
gidA
Glucose inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.
   
 
 0.691
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
     0.511
trmL
SpoU rRNA methylase family protein; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
     
 0.503
BPSL0710
Similar to Clostridium perfringens probable ATP/GTP binding protein cpe2070 SWALL:Q8XIP5 (EMBL:AP003192) (356 aa) fasta scores: E(): 3.6e-26, 34.96% id in 306 aa, and to Campylobacter jejuni putative ATP/GTP binding protein cj0500 SWALL:Q9PI09 (EMBL:AL139075) (332 aa) fasta scores: E(): 1.1e-20, 32.45% id in 305 aa, and to Escherichia coli O157:H7 putative capsule anchoring protein ybbB or z0657 or ecs0564 SWALL:Q8XCZ2 (EMBL:AE005231) (364 aa) fasta scores: E(): 3.5e-17, 32.44% id in 336 aa, and to Escherichia coli hypothetical protein ybbb ybbb or b0503 SWALL:YBBB_ECOLI (SWALL:P33667) [...]
  
   
 0.481
soxD
Similar to Corynebacterium sp. sarcosine oxidase delta subunit SoxD SWALL:SOXD_CORS1 (SWALL:Q46336) (98 aa) fasta scores: E(): 1.9e-19, 55.81% id in 86 aa, and to Ralstonia solanacearum probable sarcosine oxidase SoxD2 or rsc1102 or rs04055 SWALL:Q8Y0E2 (EMBL:AL646062) (98 aa) fasta scores: E(): 3.4e-31, 76.66% id in 90 aa, and to Ralstonia solanacearum probable sarcosine oxidase SoxD1 or rsp0047 or rs02022 SWALL:Q8XTQ9 (EMBL:AL646076) (107 aa) fasta scores: E(): 6.9e-30, 74.72% id in 91 aa.
  
 
 0.457
BPSS1719
Putative succinate dehydrogenase; Similar to Ralstonia solanacearum putative transmembrane succinate dehydrogenase sdhd or rsc1995 or rs03563 SWALL:Q8XXW8 (EMBL:AL646067) (121 aa) fasta scores: E(): 1.2e-35, 71.31% id in 122 aa, and to Escherichia coli, Escherichia coli O6, and Shigella flexneri succinate dehydrogenase hydrophobic membrane anchor protein sdhd or b0722 or c0800 or sf0575 SWALL:DHSD_ECOLI (SWALL:P10445) (115 aa) fasta scores: E(): 1.7e-10, 32.69% id in 104 aa.
  
    0.454
rlmN
Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.
  
  
 0.445
dadX
Alanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
  
  
 0.437
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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