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BPSL0116 BPSL0116 serC-2 serC-2 serC serC gpmA gpmA serA serA BPSL2902 BPSL2902 BPSL2957 BPSL2957 rplF rplF BPSL2494 BPSL2494 rplB rplB rplQ rplQ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BPSL0116D-isomer specific 2-hydroxyacid dehydrogenase; Similar to Escherichia coli 2-ketogluconate reductase TkrA SWALL:TKRA_ECOLI (SWALL:P37666) (324 aa) fasta scores: E(): 8.3e-17, 28% id in 325 aa, and to Ralstonia solanacearum putative D-3-phosphoglycerate dehydrogenase oxidoreductase protein rsc0016 or rs01838 SWALL:Q8Y3G4 (EMBL:AL646057) (353 aa) fasta scores: E(): 8.8e-100, 72.72% id in 341 aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (338 aa)    
Predicted Functional Partners:
serC-2
Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 0.969
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 0.969
gpmA
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
   
 0.914
serA
D-3-phosphoglycerate dehydrogenase; Similar to Escherichia coli, and Escherichia coli O157:H7 D-3-phosphoglycerate dehydrogenase SerA or b2913 or z4251 or ecs3784 SWALL:SERA_ECOLI (SWALL:P08328) (409 aa) fasta scores: E(): 3.4e-73, 54.52% id in 398 aa, and to Bordetella pertussis D-3-phosphoglycerate dehydrogenase homolog SerA SWALL:O30440 (EMBL:AF006000) (399 aa) fasta scores: E(): 9.7e-79, 57.14% id in 399 aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
  
 
0.905
BPSL2902
Putative phosphoglycerate mutase; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri probable phosphoglycerate mutase GpmB or b4395 or z5997 or ecs5353 or sf4427 SWALL:GPMB_ECOLI (SWALL:P36942) (215 aa) fasta scores: E(): 1.7e-12, 36.19% id in 221 aa, and to Ralstonia solanacearum putative phosphoglycerate mutase 2 protein rsc0499 or rs05023 SWALL:Q8Y237 (EMBL:AL646059) (227 aa) fasta scores: E(): 1.8e-33, 46.84% id in 222 aa.
  
 
 0.904
BPSL2957
Similar to Ralstonia solanacearum hypothetical protein RSC2765 or RS00089 SWALL:Q8XVR4 (EMBL:AL646071) (198 aa) fasta scores: E(): 9e-39, 60.41% id in 192 aa. C-terminal region is similar to Xylella fastidiosa conserved hypothetical protein SWALL:Q87A41 (EMBL:AE012560) (138 aa) fasta scores: E(): 0.00017, 31.2% id in 125 aa. Possible alternative translational start site after codon 55.
  
     0.639
rplF
50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
    
   0.618
BPSL2494
Putative membrane protein; Similar to Ralstonia solanacearum probable transmembrane protein rsc0929 or rs04485 SWALL:Q8Y0W4 (EMBL:AL646061) (151 aa) fasta scores: E(): 1.1e-29, 56.66% id in 150 aa.
 
     0.569
rplB
50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
    
   0.559
rplQ
Similar to Escherichia coli 50S ribosomal protein L17 RplQ or b3294 or z4664 or ecs4159 SWALL:RL17_ECOLI (SWALL:P02416) (127 aa) fasta scores: E(): 4.4e-31, 71.54% id in 123 aa.
   
   0.549
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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