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BPSL0118 BPSL0118 recQ recQ recA recA BPSL0763 BPSL0763 BPSL0750 BPSL0750 polA polA dnaN dnaN BPSL1970 BPSL1970 ssb ssb BPSL1437 BPSL1437 glt1 glt1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BPSL0118Similar to Escherichia coli DNA topoisomerase III TopB SWALL:TOP3_ECOLI (SWALL:P14294) (653 aa) fasta scores: E(): 2.1e-57, 33.71% id in 620 aa, and to Ralstonia solanacearum probable DNA topoisomerase III protein rsc0066 or rs02245 SWALL:Q8Y3B4 (EMBL:AL646057) (877 aa) fasta scores: E(): 0, 80.04% id in 872 aa. (869 aa)    
Predicted Functional Partners:
recQ
Similar to Escherichia coli ATP-dependent DNA helicase RecQ or b3822 SWALL:RECQ_ECOLI (SWALL:P15043) (607 aa) fasta scores: E(): 2.8e-77, 44.62% id in 614 aa, and to Ralstonia solanacearum probable ATP-dependent DNA helicase protein RecQ or Rsc3025 or Rs04732 SWALL:Q8XV07 (EMBL:AL646073) (637 aa) fasta scores: E(): 7.7e-178, 72.38% id in 630 aa.
 
 0.986
recA
Putative recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.891
BPSL0763
Putative helicase SNF2 family protein; Similar to Bacteroides nodosus putative DEAH ATP-dependent helicase SWALL:O32494 (EMBL:U20246) (965 aa) fasta scores: E(): 2.4e-28, 28.84% id in 780 aa, and to Xanthomonas campestris helicase xcc0524 SWALL:AAM39840 (EMBL:AE012150) (967 aa) fasta scores: E(): 1.8e-11, 25.36% id in 962 aa, and to Halobacterium sp. similar to Escherichia coli vng5141g or vng6139G SWALL:O52003 (EMBL:AF016485) (979 aa) fasta scores: E(): 1.9e-10, 27.33% id in 995 aa. Possible alternative translational start site.
  
 
 0.858
BPSL0750
Hypothetical protein; C-terminal region is similar to Escherichia coli O157:H7 hypothetical protein z0331 or ecs0295 SWALL:Q8X7J2 (EMBL:AE005203) (188 aa) fasta scores: E(): 4.3e-09, 27.52% id in 178 aa.
  
 0.856
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.848
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
 
 
 0.802
BPSL1970
Calcineurin-like phosphoesterase; Similar to Pseudomonas aeruginosa hypothetical protein pa0544 SWALL:Q9I5Z2 (EMBL:AE004490) (247 aa) fasta scores: E(): 1.9e-09, 36.27% id in 317 aa. Note: the central region of BPSL1970 does not present any similarities in the databases.
  
 0.792
ssb
Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
  
 
 0.787
BPSL1437
Similar to Escherichia coli DNA polymerase III, delta' subunit HolB or b1099 SWALL:HOLB_ECOLI (SWALL:P28631) (334 aa) fasta scores: E(): 4e-11, 34.82% id in 290 aa, and to Ralstonia solanacearum probable DNA polymerase III rsc1785 or rs04183 SWALL:Q8XYH3 (EMBL:AL646066) (336 aa) fasta scores: E(): 8.5e-47, 55.71% id in 341 aa.
  
 0.773
glt1
Glutamate synthase large subunit; Similar to Synechocystis sp. ferredoxin-dependent glutamate synthase 2 GltS or Sll1499 SWALL:GLTS_SYNY3 (SWALL:P55038) (1556 aa) fasta scores: E(): 0, 43.8% id in 1573 aa, and to Ralstonia solanacearum probable glutamate synthase GltB or Rsc2965 or Rs01332 SWALL:Q8XV66 (EMBL:AL646072) (1582 aa) fasta scores: E(): 0, 83.76% id in 1564 aa.
  
  
 0.767
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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