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BPSL0515 BPSL0515 coaD coaD ftsY ftsY BPSL0077 BPSL0077 der der trmE trmE cmk cmk gmk gmk rlmH rlmH BPSL1532 BPSL1532 era era
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BPSL0515Similar to Ralstonia solanacearum hypothetical protein rsc0389 or rs03357 SWALL:Q8Y2E7 (EMBL:AL646059) (215 aa) fasta scores: E(): 3.1e-31, 52.31% id in 216 aa, and to Xanthomonas campestris hypothetical protein xcc2392 SWALL:AAM41670 (EMBL:AE012348) (207 aa) fasta scores: E(): 6.3e-24, 47.57% id in 206 aa. (208 aa)    
Predicted Functional Partners:
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
 
  
 0.941
ftsY
Putative cell division protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
 
   
 0.830
BPSL0077
Conserved hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.
  
    0.666
der
Putative GTPase; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
 
    0.636
trmE
Putative tRNA modification GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
 
     0.595
cmk
Cytidylate kinase; Similar to Escherichia coli, and Escherichia coli O157:H7 cytidylate kinase cmk or mssa or b0910 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 1.3e-36, 53.91% id in 217 aa, and to Bordetella bronchiseptica cytidylate kinase cmK SWALL:KCY_BORBR (SWALL:Q9RND6) (223 aa) fasta scores: E(): 2.6e-43, 62.26% id in 212 aa.
 
    0.556
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
 
     0.545
rlmH
Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.
 
   
 0.521
BPSL1532
Putative ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
 
  
 0.510
era
GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
 
     0.510
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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