STRINGSTRING
hisC1 hisC1 hisB hisB hisD hisD pheA pheA BPSS0339 BPSS0339 BPSL1724 BPSL1724 BPSL0409 BPSL0409 BPSL1415 BPSL1415 dadA dadA dadA-2 dadA-2 tyrB tyrB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisC1Similar to Lactococcus lactis histidinol-phosphate aminotransferase HisC SWALL:HIS8_LACLA (SWALL:Q02135) (360 aa) fasta scores: E(): 1.3e-55, 46.57% id in 350 aa, and to Rhizobium meliloti histidinol-phosphate aminotransferase 2 r03268 or smc03885 SWALL:HI82_RHIME (SWALL:Q92L21) (351 aa) fasta scores: E(): 2e-76, 61.01% id in 354 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)    
Predicted Functional Partners:
hisB
Similar to Azospirillum brasilense imidazoleglycerol-phosphate dehydratase HisB SWALL:HIS7_AZOBR (SWALL:P18787) (207 aa) fasta scores: E(): 1.3e-40, 56.77% id in 192 aa, and to Escherichia coli histidine biosynthesis bifunctional protein Hisb [includes: histidinol-phosphatase (EC 3.1.3.15); imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IgpD)] HisB or b2022 SWALL:HIS7_ECOLI (SWALL:P06987) (355 aa) fasta scores: E(): 8.2e-33, 49.48% id in 194 aa.
 
 0.994
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.968
pheA
Similar to many involved in Phenylalanine biosynthesis: Neisseria gonorrhoeae P-protein [includes: chorismate mutase (EC 5.4.99.5) (cm); prephenate dehydratase (EC 4.2.1.51) (pdt)] PheA SWALL:PHEA_NEIGO (SWALL:Q9ZHY3) (362 aa) fasta scores: E(): 1.8e-64, 50% id in 362 aa, Ralstonia solanacearum probable bifunctional protein: chorismate mutase and prephenate dehydratase PheA or rsc0904 or rs04511 SWALL:Q8Y0Y9 (EMBL:AL646061) (371 aa) fasta scores: E(): 9.6e-85, 61.45% id in 358 aa and to Pseudomonas stutzeri p-protein PheA SWALL:PHEA_PSEST (SWALL:P27603) (365 aa) fasta scores: E(): 3.4e [...]
 
 
 0.957
BPSS0339
Putative amino acid dioxygenase; Similar to Pseudomonas putida 4-hydroxyphenylpyruvate dioxygenase, putative pp2554 SWALL:AAN68163 (EMBL:AE016783) (635 aa) fasta scores: E(): 2.8e-61, 53.44% id in 683 aa. CDS contains region with additional internal amino acids (residues 272 to 338) in comparison to orthologues.
    
 0.924
BPSL1724
Similar to Anabaena sp. histidinol-phosphate aminotransferase 1 HisC1 or alr2092 SWALL:HI81_ANASP (SWALL:Q8YV89) (353 aa) fasta scores: E(): 3.1e-20, 31.17% id in 324 aa, and to Halobacterium volcanii histidinol-phosphate aminotransferase HisC SWALL:HIS8_HALVO (SWALL:P17736) (361 aa) fasta scores: E(): 7.6e-18, 30.74% id in 322 aa.
  
  
 
0.920
BPSL0409
Putative D-amino acid aminotransferase; Similar to Bacillus licheniformis D-alanine aminotransferase Dat SWALL:DAAA_BACLI (SWALL:P54692) (283 aa) fasta scores: E(): 8.7e-28, 40.42% id in 282 aa, and to Listeria innocua D-alanine aminotransferase lin1660 SWALL:DAAA_LISIN (SWALL:Q92B90) (289 aa) fasta scores: E(): 1.8e-27, 36.74% id in 283 aa.
  
 
 0.917
BPSL1415
Similar to Escherichia coli, and Escherichia coli O157:H7 D-amino acid dehydrogenase small subunit DadA or DadR or b1189 or z1952 or ecs1684 SWALL:DADA_ECOLI (SWALL:P29011) (432 aa) fasta scores: E(): 1.4e-17, 27.89% id in 441 aa, and to Rhizobium leguminosarum D-amino acid dehydrogenase small subunit DadA SWALL:DADA_RHILV (SWALL:Q9RAE6) (416 aa) fasta scores: E(): 5.2e-24, 31.33% id in 434 aa.
  
  
 0.915
dadA
D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family.
  
  
 0.914
dadA-2
Putative D-amino acid dehydrogenase small subunit; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 D-amino acid dehydrogenase small subunit DadA or DadR or b1189 or c1638 or z1952 or ecs1684 SWALL:DADA_ECOLI (SWALL:P29011) (432 aa) fasta scores: E(): 5.6e-51, 37.85% id in 420 aa, and to Pseudomonas aeruginosa D-amino acid dehydrogenase 2 small subunit pa5084 SWALL:DAD2_PSEAE (SWALL:Q9HU99) (416 aa) fasta scores: E(): 1e-68, 51.44% id in 414 aa.
  
  
 0.912
tyrB
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB or b4054 SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 1.3e-80, 54.63% id in 399 aa, and to Pseudomonas aeruginosa aspartate aminotransferase AspC or pa3139 SWALL:AAT_PSEAE (SWALL:P72173) (398 aa) fasta scores: E(): 2.6e-111, 73.86% id in 398 aa. Note: Also similar to BPSS0808 (401 aa) fasta scores: E(): 7.1e-72, 53.149% identity in 397 aa overlap.
   
 
 0.911
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.