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argH argH argG-2 argG-2 argG argG arcA arcA purB purB argA argA argJ argJ BPSS0372 BPSS0372 argB argB mdh mdh fumC fumC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
argHSimilar to Escherichia coli argininosuccinate lyase ArgH or b3960 SWALL:ARLY_ECOLI (SWALL:P11447) (457 aa) fasta scores: E(): 9.8e-72, 44.97% id in 458 aa, to Pseudomonas aeruginosa argininosuccinate lyase ArgH or pa5263 SWALL:ARLY_PSEAE (SWALL:P50987) (464 aa) fasta scores: E(): 1.5e-110, 64.51% id in 465 aa, and to Ralstonia solanacearum argininosuccinate lyase rsc2363 or rs01183 SWALL:ARLY_RALSO (SWALL:Q8XWV7) (471 aa) fasta scores: E(): 1.5e-143, 82.09% id in 469 aa. (469 aa)    
Predicted Functional Partners:
argG-2
Similar to Streptomyces clavuligerus argininosuccinate synthase ArgG SWALL:ASSY_STRCL (SWALL:P50986) (397 aa) fasta scores: E(): 8.4e-49, 35.78% id in 394 aa, and to Thermoanaerobacter tengcongensis argininosuccinate synthase tte2494 SWALL:Q8R7C2 (EMBL:AE013190) (410 aa) fasta scores: E(): 1.9e-70, 44.92% id in 394 aa.
 
 
 0.991
argG
Similar to Escherichia coli argininosuccinate synthase ArgG SWALL:ASSY_ECOLI (SWALL:P22767) (446 aa) fasta scores: E(): 1.1e-138, 77.87% id in 443 aa, and to Neisseria meningitidis argininosuccinate synthase nma0303 SWALL:Q9JWM1 (EMBL:AL162752) (447 aa) fasta scores: E(): 1.2e-144, 82.87% id in 438 aa; Belongs to the argininosuccinate synthase family. Type 2 subfamily.
 
 
 0.973
arcA
Arginine deiminase; Similar to Pseudomonas aeruginosa arginine deiminase ArcA or pa5171 SWALL:ARCA_PSEAE (SWALL:P13981) (417 aa) fasta scores: E(): 2.5e-140, 79.36% id in 412 aa, and to Rhizobium etli arginine deiminase ArcA SWALL:ARCA_RHIET (SWALL:O31017) (409 aa) fasta scores: E(): 1.1e-102, 61.42% id in 407 aa.
     
 0.911
purB
Adenylosuccinate lyase; Similar to Escherichia coli, and Escherichia coli O6 adenylosuccinate lyase PurB or b1131 or c1510 SWALL:PUR8_ECOLI (SWALL:P25739) (456 aa) fasta scores: E(): 2.5e-109, 62.55% id in 454 aa, and to Ralstonia solanacearum probable adenylosuccinate lyase protein rsc2720 or rs00002 SWALL:Q8XVV7 (EMBL:AL646071) (457 aa) fasta scores: E(): 9.1e-148, 82.41% id in 455 aa. Note: This CDS is longer in its N-terminal region than most of its database matches. It contains an alternative start codon at residue 22.
    
 0.911
argA
Putative amino-acid acetyltransferase; Similar to Escherichia coli, and Escherichia coli O157:H7 amino-acid acetyltransferase ArgA SWALL:ARGA_ECOLI (SWALL:P08205) (443 aa) fasta scores: E(): 1.5e-76, 46.89% id in 435 aa, and to Ralstonia solanacearum probable amino-acid acetyltransferase protein rsc1250 or rs02762 SWALL:Q8XZZ5 (EMBL:AL646063) (451 aa) fasta scores: E(): 3.6e-123, 71.71% id in 449 aa. CDS is extended at the N-terminus in comparison to some orthologues. Possible alternative translational start site.
 
  
 0.881
argJ
Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
 
  
 0.873
BPSS0372
Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
 0.859
argB
Putative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
  
 0.845
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.833
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 
 0.821
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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