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ilvC ilvC ilvH ilvH ilvD ilvD ilvI ilvI ilvG ilvG BPSS0414 BPSS0414 BPSS0902 BPSS0902 BPSS1879 BPSS1879 leuC leuC leuD leuD BPSS0305 BPSS0305
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)    
Predicted Functional Partners:
ilvH
Similar to Escherichia coli acetolactate synthase isozyme III small subunit IlvH or BrnP or b0078 SWALL:ILVH_ECOLI (SWALL:P00894) (163 aa) fasta scores: E(): 4.8e-31, 55.82% id in 163 aa, and to Ralstonia solanacearum probable acetolactate synthase isozyme III rsc2076 or rs03641 SWALL:Q8XXN7 (EMBL:AL646068) (163 aa) fasta scores: E(): 9.5e-49, 88.34% id in 163 aa.
 
 
 0.999
ilvD
Similar to Lactococcus lactis dihydroxy-acid dehydratase IlvD or ll1223 SWALL:ILVD_LACLA (SWALL:Q02139) (570 aa) fasta scores: E(): 4.6e-100, 49.63% id in 554 aa, and to Ralstonia solanacearum dihydroxy-acid dehydratase IlvD or rsc2412 or rs02706 SWALL:ILVD_RALSO (SWALL:Q8XWR1) (557 aa) fasta scores: E(): 1.2e-186, 86.33% id in 556 aa; Belongs to the IlvD/Edd family.
 
 
 0.995
ilvI
Similar to Escherichia coli acetolactate synthase isozyme III large subunit IlvI or b0077 SWALL:ILVI_ECOLI (SWALL:P00893) (574 aa) fasta scores: E(): 9e-132, 57.61% id in 571 aa, and to Ralstonia solanacearum probable acetolactate synthase isozyme III rsc2077 or rs03642 SWALL:Q8XXN6 (EMBL:AL646068) (585 aa) fasta scores: E(): 6.5e-194, 79.38% id in 587 aa. Note: This CDS is longer in its N-terminal region than most of its database matches.
 
 
 0.993
ilvG
Similar to Escherichia coli acetolactate synthase isozyme II large subunit IlvG or b3767 SWALL:ILVG_ECOLI (SWALL:P00892) (548 aa) fasta scores: E(): 1.7e-45, 30.91% id in 537 aa, and to Brucella melitensis acetolactate synthase large subunit BmeII0351 SWALL:Q8YD26 (EMBL:AE009672) (564 aa) fasta scores: E(): 5.1e-126, 59.56% id in 554 aa; Belongs to the TPP enzyme family.
 
 
 0.992
BPSS0414
Similar to Caulobacter crescentus acetolactate synthase, large subunit cc2100 SWALL:Q9A6J3 (EMBL:AE005883) (582 aa) fasta scores: E(): 3.3e-53, 36.34% id in 575 aa, and to Bacillus subtilis acetolactate synthase large subunit IlvB SWALL:ILVB_BACSU (SWALL:P37251) (573 aa) fasta scores: E(): 7.6e-53, 33.74% id in 572 aa; Belongs to the TPP enzyme family.
 
 
 0.985
BPSS0902
Putative thiamine pyrophosphate enzyme; Similar to Pseudomonas aeruginosa probable decarboxylase pa3506 SWALL:Q9HYA3 (EMBL:AE004771) (560 aa) fasta scores: E(): 1.8e-134, 66.13% id in 561 aa. Weakly similar to Escherichia coli acetolactate synthase isozyme I large subunit IlvB SWALL:ILVB_ECOLI (SWALL:P08142) (562 aa) fasta scores: E(): 1.8e-32, 28.57% id in 532 aa; Belongs to the TPP enzyme family.
 
 
 0.975
BPSS1879
Similar to Bacillus subtilis acetolactate synthase AlsS SWALL:ILVX_BACSU (SWALL:Q04789) (571 aa) fasta scores: E(): 2.8e-57, 32.78% id in 543 aa, and to Pseudomonas aeruginosa probable acetolactate synthase large subunit pa4180 SWALL:Q9HWK1 (EMBL:AE004834) (547 aa) fasta scores: E(): 3.5e-155, 69.57% id in 539 aa; Belongs to the TPP enzyme family.
 
 
 0.969
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.932
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.931
BPSS0305
Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa.
  
  
 
0.921
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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