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clpP clpP clpX clpX clpA clpA hrcA hrcA clpB clpB BPSS0522 BPSS0522 BPSS0174 BPSS0174 BPSS1502 BPSS1502 BPSS0116 BPSS0116 BPSS2094 BPSS2094 clpB-2 clpB-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (217 aa)    
Predicted Functional Partners:
clpX
ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 
 0.999
clpA
Similar to Escherichia coli, and Escherichia coli O157:H7 ATP-dependent Clp protease ATP-binding subunit ClpA or LopD or b0882 or z1119 or ecs0968 SWALL:CLPA_ECOLI (SWALL:P15716) (758 aa) fasta scores: E(): 2.4e-163, 61.6% id in 750 aa, and to Ralstonia solanacearum probable ATP-dependent protease ClpA or rsc2464 or rs01141 SWALL:Q8XWL0 (EMBL:AL646070) (762 aa) fasta scores: E(): 0, 87.53% id in 762 aa, and to Pseudomonas aeruginosa ATP-binding protease component ClpA or pa2620 SWALL:Q9I0L8 (EMBL:AE004690) (758 aa) fasta scores: E(): 4.2e-175, 65.74% id in 762 aa; Belongs to the ClpA/C [...]
 
 
 0.951
hrcA
Putative heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.897
clpB
ClpB heat-shock protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
 
 
 0.842
BPSS0522
Putative ATPase; N-terminal region is similar to Escherichia coli heat shock protein ClpB or HtpM SWALL:CLPB_ECOLI (SWALL:P03815) (857 aa) fasta scores: E(): 7.4e-43, 36.28% id in 871 aa, and to Yersinia pestis putative Clp ATPase ypo0506 SWALL:Q8ZIJ2 (EMBL:AJ414143) (867 aa) fasta scores: E(): 1.6e-136, 48.66% id in 861 aa; Belongs to the ClpA/ClpB family.
 
 
 0.839
BPSS0174
Putative chaperone; Similar to Salmonella typhimurium, and Salmonella enterica subsp. enterica serovar Typhimurium putative ATPase with chaperone activity stm0272 or sciG SWALL:Q93IS9 (EMBL:AE008707) (879 aa) fasta scores: E(): 1.4e-75, 58.54% id in 948 aa, and to Yersinia enterocolitica Clp protease-associated protein ClpB SWALL:Q9F746 (EMBL:AF285784) (890 aa) fasta scores: E(): 1.7e-69, 55.59% id in 939 aa. Note: Also similar to BPSS1502 (1013 aa) fasta scores: E(): 1.8e-94, 44.865% identity in 1003 aa overlap; Belongs to the ClpA/ClpB family.
 
 
 0.838
BPSS1502
Putative Clp-type ATPase chaperone protein; Similar to Yersinia enterocolitica clp protease-associated protein ClpB SWALL:Q9F746 (EMBL:AF285784) (890 aa) fasta scores: E(): 7.8e-55, 41.06% id in 962 aa, and to Ralstonia solanacearum putative ClpA/B-type chaperone protein rsp0749 or rs01959 SWALL:Q8XRT2 (EMBL:AL646080) (905 aa) fasta scores: E(): 4.1e-66, 47.08% id in 962 aa; Belongs to the ClpA/ClpB family.
 
 
 0.838
BPSS0116
Putative chaperone-related protein; Similar to Salmonella typhimurium, and Salmonella enterica subsp. enterica serovar Typhimurium putative ATPase with chaperone activity, homolog of Yersinia ClpB stm0272 or SciG SWALL:Q93IS9 (EMBL:AE008707) (879 aa) fasta scores: E(): 4.1e-196, 63.58% id in 865 aa, and to Yersinia pestis putative Clp ATPase ClpB or ypo0506 or y3669 SWALL:Q8ZIJ2 (EMBL:AJ414143) (867 aa) fasta scores: E(): 1.9e-121, 44.6% id in 843 aa; Belongs to the ClpA/ClpB family.
 
 
 0.837
BPSS2094
Putative Clp protease ATPase; Similar to Escherichia coli ATPase subunit of an intracellular ATP-dependent protease ClpB or HtpM SWALL:CLPB_ECOLI (SWALL:P03815) (857 aa) fasta scores: E(): 1.1e-92, 38.66% id in 869 aa, and to Yersinia pestis Clp ATPase ypo2946 SWALL:Q8ZCN5 (EMBL:AJ414154) (891 aa) fasta scores: E(): 5.8e-161, 56.37% id in 855 aa. Similar to BPSL3101, 53.114% identity (53.539% ungapped) in 883 aa overlap, and to BPSS0174, 55.792% identity (60.624% ungapped) in 941 aa overlap, and to BPSS0116, 57.931% identity (58.810% ungapped) in 870 aa overlap; Belongs to the ClpA/Clp [...]
 
 
 0.837
clpB-2
Protease associated ATPase ClpB; Similar to Escherichia coli ClpB protein or HtpM or b2592 or z3886 or ecs3455 SWALL:CLPB_ECOLI (SWALL:P03815) (857 aa) fasta scores: E(): 2.5e-88, 38.75% id in 867 aa, and to Yersinia enterocolitica Clp protease-associated protein ClpB SWALL:Q9F746 (EMBL:AF285784) (890 aa) fasta scores: E(): 5.8e-134, 49.31% id in 876 aa; Belongs to the ClpA/ClpB family.
 
 
 0.835
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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