STRINGSTRING
hom hom thrC thrC asd asd metXS metXS dapA dapA thrB thrB dapA-2 dapA-2 BPSL0936 BPSL0936 ilvH ilvH ask ask BPSL0476 BPSL0476
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
homSimilar to Pseudomonas aeruginosa homoserine dehydrogenase Hom or pa3736 SWALL:DHOM_PSEAE (SWALL:P29365) (434 aa) fasta scores: E(): 1e-98, 63.12% id in 442 aa, and to Ralstonia solanacearum probable homoserine dehydrogenase oxidoreductase protein rsc1327 or rs02849 SWALL:Q8XZR8 (EMBL:AL646064) (439 aa) fasta scores: E(): 8.2e-121, 78.73% id in 442 aa. (442 aa)    
Predicted Functional Partners:
thrC
Threonine synthase; Similar to Corynebacterium glutamicum threonine synthase ThrC or cgl2220 SWALL:THRC_CORGL (SWALL:P23669) (481 aa) fasta scores: E(): 8.6e-100, 57.97% id in 483 aa, and to Ralstonia solanacearum probable threonine synthase protein rsc1328 or rs02850 SWALL:Q8XZR7 (EMBL:AL646064) (481 aa) fasta scores: E(): 5.1e-144, 76.55% id in 482 aa.
 
 
 0.991
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
 0.972
metXS
Putative homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
 
 0.955
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.939
thrB
Homoserine kinase; Similar to Methylobacillus flagellatum homoserine kinase ThrB SWALL:KHSE_METFL (SWALL:Q9RAM6) (319 aa) fasta scores: E(): 2e-31, 44.2% id in 319 aa, and to Pseudomonas aeruginosa homoserine kinase pa5495 SWALL:KHSE_PSEAE (SWALL:P29364) (316 aa) fasta scores: E(): 6.4e-25, 43.08% id in 318 aa; Belongs to the pseudomonas-type ThrB family.
 
  
 0.933
dapA-2
Dihydrodipicolinate synthetase family protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.931
BPSL0936
Putative dihydrodipicolinate synthetase; Similar to Methanopyrus kandleri dihydrodipicolinate synthase DapA or mk1607 SWALL:Q8TUZ4 (EMBL:AE010450) (300 aa) fasta scores: E(): 1.7e-25, 31.48% id in 289 aa, and to Pseudomonas aeruginosa probable dihydrodipicolinate synthetase pa0223 SWALL:Q9I6R5 (EMBL:AE004460) (293 aa) fasta scores: E(): 4e-68, 61.43% id in 293 aa, and to Vibrio sp. CH-291 hypothetical protein SWALL:Q93IK7 (EMBL:AJ314791) (295 aa) fasta scores: E(): 9.2e-63, 57.58% id in 290 aa.
 
 
 0.930
ilvH
Similar to Escherichia coli acetolactate synthase isozyme III small subunit IlvH or BrnP or b0078 SWALL:ILVH_ECOLI (SWALL:P00894) (163 aa) fasta scores: E(): 4.8e-31, 55.82% id in 163 aa, and to Ralstonia solanacearum probable acetolactate synthase isozyme III rsc2076 or rs03641 SWALL:Q8XXN7 (EMBL:AL646068) (163 aa) fasta scores: E(): 9.5e-49, 88.34% id in 163 aa.
 
  
 0.917
ask
Aspartokinase; Similar to Mycobacterium smegmatis aspartokinase Ask SWALL:AK_MYCSM (SWALL:P41403) (421 aa) fasta scores: E(): 2e-66, 47.96% id in 417 aa, and to Methylobacillus glycogenes aspartate kinase LysC SWALL:Q8RU02 (EMBL:AB038354) (408 aa) fasta scores: E(): 7.2e-104, 71.56% id in 415 aa; Belongs to the aspartokinase family.
 
 0.917
BPSL0476
Similar to Haemophilus influenzae diaminobutyrate--2-oxoglutarate aminotransferase Dat SWALL:DAT_HAEIN (SWALL:P44951) (454 aa) fasta scores: E(): 2.2e-76, 49.51% id in 412 aa, and to Rhizobium meliloti diaminobutyrate--2-oxoglutarate aminotransferase RhbA SWALL:RHBA_RHIME (SWALL:Q9Z3R2) (470 aa) fasta scores: E(): 4.9e-91, 54.4% id in 443 aa. Similar to BPSS1635, 56.019% identity (56.674% ungapped) in 432 aa overlap; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.914
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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