STRINGSTRING
hfq hfq hfq-2 hfq-2 hflX hflX rne rne pnp pnp acpP acpP ihfA ihfA clpX clpX BPSL0498 BPSL0498 pcnB pcnB BPSL0191 BPSL0191
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hfqHfq protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (79 aa)    
Predicted Functional Partners:
hfq-2
Hfq protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.
  
  
 
0.908
hflX
Putative GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
  
  
 0.764
rne
Putative ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily.
 
 
 0.754
pnp
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
    
 
 0.721
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
   
  
 0.715
ihfA
Integration host factor alpha-subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.
   
  
 0.707
clpX
ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
  
 0.683
BPSL0498
Similar to Pseudomonas aeruginosa probable phosphotransferase protein pa3760 SWALL:Q9HXN5 (EMBL:AE004794) (842 aa) fasta scores: E(): 8e-102, 49.53% id in 860 aa. C-terminus is similar to the C-terminal region of Rhodobacter capsulatus multiphosphoryl transfer protein frub(hi) SWALL:PTF1_RHOCA (SWALL:P23388) (827 aa) fasta scores: E(): 2.7e-78, 40.73% id in 739 aa; Belongs to the PEP-utilizing enzyme family.
   
  
 0.678
pcnB
Putative polynucleotide adenylyltransferase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
    
 
 0.678
BPSL0191
Endonuclease/exonuclease/phosphatase family protein; Similar to the C-terminal region of Homo sapiens DNA repair major apurinic/ apyrimidinic endonuclease APEX or APE or HAP1 or REF1 or APX SWALL:APE1_HUMAN (SWALL:P27695) (317 aa) fasta scores: E(): 1.2e-32, 37.94% id in 253 aa, and to the full length Ralstonia solanacearum putative exodeoxyribonuclease III protein rsc0140 or rs01010 SWALL:Q8Y341 (EMBL:AL646057) (261 aa) fasta scores: E(): 5.7e-90, 79.45% id in 258 aa.
    
 
 0.664
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.