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purA purA guaB guaB purB purB purH purH purL purL BPSL2996 BPSL2996 pyrB pyrB pyrB-2 pyrB-2 guaA guaA nadB nadB argG argG
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Predicted Interactions
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purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (448 aa)    
Predicted Functional Partners:
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.995
purB
Adenylosuccinate lyase; Similar to Escherichia coli, and Escherichia coli O6 adenylosuccinate lyase PurB or b1131 or c1510 SWALL:PUR8_ECOLI (SWALL:P25739) (456 aa) fasta scores: E(): 2.5e-109, 62.55% id in 454 aa, and to Ralstonia solanacearum probable adenylosuccinate lyase protein rsc2720 or rs00002 SWALL:Q8XVV7 (EMBL:AL646071) (457 aa) fasta scores: E(): 9.1e-148, 82.41% id in 455 aa. Note: This CDS is longer in its N-terminal region than most of its database matches. It contains an alternative start codon at residue 22.
  
 0.989
purH
Similar to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (aicar transformylase); IMP cyclohydrolase (EC 3.5.4.10) (inosinicase) (IMP synthetase) (atic)] PurH or b4006 SWALL:PUR9_ECOLI (SWALL:P15639) (529 aa) fasta scores: E(): 1.5e-122, 62.28% id in 525 aa, and to Ralstonia solanacearum probable bifunctional: phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase transmembrane protein rsc0504 or rs05018 SWALL:Q8Y232 (EMBL:AL646059) (524 aa) fasta scores: E(): 4.6e-170 [...]
  
 0.985
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
  
 0.973
BPSL2996
Similar to Bacillus subtilis hypoxanthine-guanine phosphoribosyltransferase HprT or Hpt SWALL:HPRT_BACSU (SWALL:P37472) (180 aa) fasta scores: E(): 2.5e-12, 29.94% id in 177 aa, and to Ralstonia solanacearum probable hypoxanthine phosphoribosyltransferase transmembrane protein rsc2812 or rs00293 SWALL:Q8XVL8 (EMBL:AL646072) (182 aa) fasta scores: E(): 4.2e-52, 76.53% id in 179 aa.
  
 
 0.955
pyrB
Similar to Ralstonia solanacearum aspartate carbamoyltransferase PyrB or rsc0678 or rs01583 SWALL:PYRB_RALSO (SWALL:Q8Y1L2) (323 aa) fasta scores: E(): 1.7e-105, 88.64% id in 317 aa, and to Pseudomonas aeruginosa aspartate carbamoyltransferase PyrB or pa0402 SWALL:PYRB_PSEAE (SWALL:Q59653) (334 aa) fasta scores: E(): 4e-81, 69.8% id in 308 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 
 0.947
pyrB-2
Similar to Burkholderia cepacia aspartate transcarbamoylase PyrB SWALL:Q9F9H3 (EMBL:AF192346) (431 aa) fasta scores: E(): 1.6e-157, 92.82% id in 432 aa, and to Pisum sativum aspartate carbamoyltransferase 2, chloroplast precursor PyrB2 SWALL:PYB2_PEA (SWALL:Q43087) (385 aa) fasta scores: E(): 2e-42, 43.61% id in 321 aa, and to Pisum sativum aspartate carbamoyltransferase 3, chloroplast precursor PyrB3 SWALL:PYB3_PEA (SWALL:Q43064) (391 aa) fasta scores: E(): 2.3e-42, 42.94% id in 333 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
 
 
 0.935
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
  
 0.933
nadB
Putative L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
  
  
 0.932
argG
Similar to Escherichia coli argininosuccinate synthase ArgG SWALL:ASSY_ECOLI (SWALL:P22767) (446 aa) fasta scores: E(): 1.1e-138, 77.87% id in 443 aa, and to Neisseria meningitidis argininosuccinate synthase nma0303 SWALL:Q9JWM1 (EMBL:AL162752) (447 aa) fasta scores: E(): 1.2e-144, 82.87% id in 438 aa; Belongs to the argininosuccinate synthase family. Type 2 subfamily.
  
 
 0.927
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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