STRINGSTRING
BPSL1542 BPSL1542 BPSL1716 BPSL1716 metE metE metH2 metH2 BPSS0190 BPSS0190 BPSS1766 BPSS1766 metH1 metH1 metZ metZ ahcY ahcY BPSL2618 BPSL2618 hom hom
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
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[Homology]
Score
BPSL1542Similar to Escherichia coli cystathionine beta-lyase MetC or b3008 SWALL:METC_ECOLI (SWALL:P06721) (395 aa) fasta scores: E(): 5.8e-47, 37.84% id in 362 aa, and to Ralstonia solanacearum putative cystathionine beta-lyase rsc1639 or rs04013 SWALL:Q8XYW7 (EMBL:AL646065) (404 aa) fasta scores: E(): 3.2e-94, 64.43% id in 388 aa. (394 aa)    
Predicted Functional Partners:
BPSL1716
Similar to Rhizobium loti cysteine synthase mll9227 SWALL:Q981U9 (EMBL:AP003015) (351 aa) fasta scores: E(): 4.2e-53, 45.74% id in 341 aa, and to Alcaligenes eutrophus cysteine synthase CysM SWALL:CYSM_ALCEU (SWALL:Q44004) (339 aa) fasta scores: E(): 9.2e-16, 31.35% id in 303 aa.
 
 0.974
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.957
metH2
Similar to Ralstonia solanacearum probable 5-methyltetrahydrofolate--homocysteine methyltransferase rsc0295 or rs03262 SWALL:Q8Y2P0 (EMBL:AL646058) (346 aa) fasta scores: E(): 2.9e-107, 80.29% id in 345 aa, and to the N-terminal region Escherichia coli 5-methyltetrahydrofolate--homocysteine methyltransferase MetH SWALL:METH_ECOLI (SWALL:P13009) (1226 aa) fasta scores: E(): 3.2e-72, 59.07% id in 325 aa. BPSL0385 and BPSL03856 are similar to the N- and C-terminal regions of many 5-methyltetrahydrofolate--homocysteine methyltransferases. In some organisms these two domains are also found [...]
  
 
 0.947
BPSS0190
Putative AraC-family transcriptional regulator (fragment); Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 16.0, E-value 0.049.
 
 
0.945
BPSS1766
Putative sulfurtransferase (cyanide detoxification); Similar to Escherichia coli 3-mercaptopyruvate sulfurtransferase SseA or b2521 SWALL:THTM_ECOLI (SWALL:P31142) (280 aa) fasta scores: E(): 3.6e-21, 33.09% id in 284 aa, and to Pseudomonas aeruginosa probable 3-mercaptopyruvate sulfurtransferase pa1292 SWALL:THTM_PSEAE (SWALL:Q9I452) (284 aa) fasta scores: E(): 1.5e-49, 50.17% id in 281 aa.
 
 
 0.931
metH1
Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.927
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
  
 
0.926
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.922
BPSL2618
Similar to Pseudomonas sp. 1-aminocyclopropane-1-carboxylate deaminase SWALL:1A1D_PSESP (SWALL:Q00740) (338 aa) fasta scores: E(): 6.3e-35, 42.09% id in 335 aa, Salmonella typhimurium putative 1-cyclopropane-carboxylate deaminase YedO or stm1953 SWALL:Q8ZNT7 (EMBL:AE008786) (328 aa) fasta scores: E(): 2.8e-72, 63.46% id in 323 aa, and to Pyrococcus abyssi putative 1-aminocyclopropane-1-carboxylate deaminase pab2303 SWALL:1A1D_PYRAB (SWALL:Q9V2L2) (330 aa) fasta scores: E(): 5e-32, 40.61% id in 325 aa.
     
 0.901
hom
Similar to Pseudomonas aeruginosa homoserine dehydrogenase Hom or pa3736 SWALL:DHOM_PSEAE (SWALL:P29365) (434 aa) fasta scores: E(): 1e-98, 63.12% id in 442 aa, and to Ralstonia solanacearum probable homoserine dehydrogenase oxidoreductase protein rsc1327 or rs02849 SWALL:Q8XZR8 (EMBL:AL646064) (439 aa) fasta scores: E(): 8.2e-121, 78.73% id in 442 aa.
  
 
 0.880
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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