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guaB guaB guaA guaA purA purA BPSL3430 BPSL3430 purH purH BPSL2996 BPSL2996 BPSL2566 BPSL2566 surE surE pheT pheT rpoB rpoB purM purM
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
 0.999
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.995
BPSL3430
Putative glutamine amidotransferase class-I; Similar to a family of proteins which includes putative GMP synthases eg. Ralstonia solanacearum hypothetical protein Rsc1158 or Rs04593 SWALL:Q8Y086 (EMBL:AL646063) (242 aa) fasta scores: E(): 1.4e-32, 47.39% id in 230 aa, and to Neisseria meningitidis GMP synthase [glutamine-hydrolyzing] GuaA or Nmb1920 SWALL:GUAA_NEIMB (SWALL:Q9JXR2) (521 aa) fasta scores: E(): 9.5e-06, 27.68% id in 177 aa.
  
 
 0.979
purH
Similar to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (aicar transformylase); IMP cyclohydrolase (EC 3.5.4.10) (inosinicase) (IMP synthetase) (atic)] PurH or b4006 SWALL:PUR9_ECOLI (SWALL:P15639) (529 aa) fasta scores: E(): 1.5e-122, 62.28% id in 525 aa, and to Ralstonia solanacearum probable bifunctional: phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase transmembrane protein rsc0504 or rs05018 SWALL:Q8Y232 (EMBL:AL646059) (524 aa) fasta scores: E(): 4.6e-170 [...]
 
 
 0.977
BPSL2996
Similar to Bacillus subtilis hypoxanthine-guanine phosphoribosyltransferase HprT or Hpt SWALL:HPRT_BACSU (SWALL:P37472) (180 aa) fasta scores: E(): 2.5e-12, 29.94% id in 177 aa, and to Ralstonia solanacearum probable hypoxanthine phosphoribosyltransferase transmembrane protein rsc2812 or rs00293 SWALL:Q8XVL8 (EMBL:AL646072) (182 aa) fasta scores: E(): 4.2e-52, 76.53% id in 179 aa.
  
 
 0.957
BPSL2566
Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
 0.953
surE
Acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.943
pheT
Similar to Escherichia coli phenylalanyl-tRNA synthetase beta chain PheT or b1713 SWALL:SYFB_ECOLI (SWALL:P07395) (795 aa) fasta scores: E(): 3.2e-119, 41.84% id in 815 aa, and to Ralstonia solanacearum probable phenylalanyl-tRNA synthetase beta chain protein rsc1582 or rs05825 SWALL:Q8XZ24 (EMBL:AL646065) (809 aa) fasta scores: E(): 0, 67.53% id in 810 aa.
  
  
 0.924
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.864
purM
Similar to Escherichia coli phosphoribosylformylglycinamidine cyclo-ligase PurM or PurG or b2499 SWALL:PUR5_ECOLI (SWALL:P08178) (344 aa) fasta scores: E(): 2.9e-78, 59.76% id in 343 aa, and to Ralstonia solanacearum probable phosphoribosylformylglycinamidine cyclo-ligase PurM or rsc2623 or rs00927 SWALL:Q8XW52 (EMBL:AL646071) (353 aa) fasta scores: E(): 1.9e-108, 81.21% id in 346 aa, and to Neisseria meningitidis putative phosphoribosylformylglycinamidine cyclo-ligase PurM or nma1421 SWALL:Q9JUA2 (EMBL:AL162755) (344 aa) fasta scores: E(): 7.4e-90, 68.73% id in 339 aa.
 
  
 0.856
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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