STRINGSTRING
lpxD lpxD lpxB lpxB wcbS wcbS envA envA BPSL2150 BPSL2150 lpxA lpxA lpxH lpxH bamA bamA fabZ fabZ waaA waaA kdsA kdsA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (361 aa)    
Predicted Functional Partners:
lpxB
Putative lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
 
 0.994
wcbS
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
 
 
 0.990
envA
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
 
 
 0.990
BPSL2150
Putative outer membrane protein; Similar to Ralstonia solanacearum probable transmembrane protein rsc1413 or rs05279 SWALL:Q8XZI2 (EMBL:AL646064) (184 aa) fasta scores: E(): 6.5e-32, 71.25% id in 160 aa, and to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 histone-like protein HLP-1 precursor HlpA or Skp or OmpH or b0178 or c0215 or z0190 or ecs0180 SWALL:HLPA_ECOLI (SWALL:P11457) (161 aa) fasta scores: E(): 1.3e-05, 35.44% id in 158 aa; Belongs to the skp family.
  
  
 0.967
lpxA
acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
 
0.948
lpxH
Putative UDP-2,3-diacylglucosamine hydrolase (lipid A biosynthesis related protein); Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  
  
 0.943
bamA
Putative outer membrane protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
  
 0.942
fabZ
(3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
 
  
 0.930
waaA
Probable 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
   
 0.902
kdsA
Similar to Escherichia coli 2-dehydro-3-deoxyphosphooctonate aldolase KdsA or b1215 SWALL:KDSA_ECOLI (SWALL:P17579) (284 aa) fasta scores: E(): 1.7e-73, 68.11% id in 276 aa, and to Neisseria meningitidis 2-dehydro-3-deoxyphosphooctonate aldolase KdsA or nmb1283 SWALL:KDSA_NEIMB (SWALL:Q9JZ55) (280 aa) fasta scores: E(): 2.6e-75, 70.35% id in 280 aa, and to Yersinia pestis 2-dehydro-3-deoxyphosphooctonate aldolase KdsA or ypo2021 or y2286 SWALL:KDSA_YERPE (SWALL:Q8ZEX4) (284 aa) fasta scores: E(): 3e-75, 69.56% id in 276 aa; Belongs to the KdsA family.
 
  
 0.879
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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