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pyrG pyrG guaA guaA ndk ndk dcd dcd rpsB rpsB BPSL2356 BPSL2356 pnp pnp argS argS rplF rplF rplM rplM rplE rplE
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (553 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
 
 0.978
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
 
 
 0.949
dcd
Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP.
  
 
 0.930
rpsB
30S ribosomal protein S2; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 30S ribosomal protein S2 RpsB or b0169 or c0204 or z0180 or ecs0171 SWALL:RS2_ECOLI (SWALL:P02351) (240 aa) fasta scores: E(): 4.9e-51, 56.01% id in 241 aa, and to Ralstonia solanacearum 30S ribosomal protein S2 rsc1404 or rs05288 SWALL:Q8XZJ1 (EMBL:AL646064) (247 aa) fasta scores: E(): 1.8e-79, 86.42% id in 243 aa; Belongs to the universal ribosomal protein uS2 family.
  
 
 0.919
BPSL2356
Conserved hypothetical protein; Similar to the C-terminal region of Alcaligenes eutrophus NrdD protein SWALL:Q9ZER4 (EMBL:AJ012479) (676 aa) fasta scores: E(): 6.4e-200, 82.62% id in 564 aa, and to and internal region Escherichia coli anaerobic ribonucleoside-triphosphate reductase NrdD or b4238 SWALL:NRDD_ECOLI (SWALL:P28903) (712 aa) fasta scores: E(): 0.0037, 21.89% id in 571 aa. CDS is truncated at the C-terminus in comparison to some orthologues. Downstream CDS has has low similarity to C-terminus of these orthologues.
     
 0.909
pnp
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
  
  
 0.902
argS
Similar to Corynebacterium glutamicum arginyl-tRNA synthetase ArgS SWALL:SYR_CORGL (SWALL:P35868) (550 aa) fasta scores: E(): 1.5e-26, 42.07% id in 599 aa, and to Ralstonia solanacearum probable arginyl-tRNA synthetase rsc0287 or rs03254 SWALL:Q8Y2P8 (EMBL:AL646058) (600 aa) fasta scores: E(): 6.2e-117, 70.18% id in 607 aa.
  
  
 0.894
rplF
50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
 
 0.894
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.891
rplE
50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
   
 
 0.887
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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