STRINGSTRING
hscA hscA dnaJ dnaJ hscB hscB htpG htpG fdx-2 fdx-2 BPSL2288 BPSL2288 grpE grpE BPSL2283 BPSL2283 iscS iscS BPSL2287 BPSL2287 BPSL0763 BPSL0763
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hscAChaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (622 aa)    
Predicted Functional Partners:
dnaJ
Putative DnaJ chaperone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwee [...]
 0.988
hscB
Putative chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 
 0.987
htpG
Chaperone protein; Molecular chaperone. Has ATPase activity.
  
 0.961
fdx-2
Ferredoxin, 2Fe-2S; Similar to Escherichia coli, and Escherichia coli O157:H7 ferredoxin, 2Fe-2S Fdx SWALL:FER_ECOLI (SWALL:P25528) (110 aa) fasta scores: E(): 5.2e-30, 68.46% id in 111 aa, and to Ralstonia solanacearum probable ferredoxin rsc1025 or rs04229 SWALL:Q8Y0L8 (EMBL:AL646062) (112 aa) fasta scores: E(): 9.5e-33, 75.22% id in 113 aa.
 
 
 0.945
BPSL2288
Conserved hypothetical protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 
 0.943
grpE
Conserved hypothetical protein (pseudogene); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Se [...]
 
 0.937
BPSL2283
Similar to Vibrio cholerae hypothetical protein vc0754 SWALL:Q9KTX6 (EMBL:AE004160) (64 aa) fasta scores: E(): 3.2e-15, 64.51% id in 62 aa, and to Escherichia coli, and Escherichia coli O157:H7 hypothetical protein b2524 or z3791 or ecs3390 SWALL:YFHJ_ECOLI (SWALL:P37096) (66 aa) fasta scores: E(): 2.3e-14, 62.5% id in 64 aa.
 
  
 0.898
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
  
 0.855
BPSL2287
HesB family protein; Similar to Ralstonia solanacearum hypothetical protein rsc1021 rsc1021 or rs04236 SWALL:Q8Y0M2 (EMBL:AL646062) (106 aa) fasta scores: E(): 4e-34, 84.76% id in 105 aa, and to Pasteurella multocida hypothetical protein Pm0320 pm0320 SWALL:Q9CNV4 (EMBL:AE006068) (107 aa) fasta scores: E(): 1.4e-31, 75.7% id in 107 aa; Belongs to the HesB/IscA family.
 
 
 0.827
BPSL0763
Putative helicase SNF2 family protein; Similar to Bacteroides nodosus putative DEAH ATP-dependent helicase SWALL:O32494 (EMBL:U20246) (965 aa) fasta scores: E(): 2.4e-28, 28.84% id in 780 aa, and to Xanthomonas campestris helicase xcc0524 SWALL:AAM39840 (EMBL:AE012150) (967 aa) fasta scores: E(): 1.8e-11, 25.36% id in 962 aa, and to Halobacterium sp. similar to Escherichia coli vng5141g or vng6139G SWALL:O52003 (EMBL:AF016485) (979 aa) fasta scores: E(): 1.9e-10, 27.33% id in 995 aa. Possible alternative translational start site.
  
 0.818
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.