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pgm pgm BPSS1835 BPSS1835 manC-2 manC-2 manC manC glk glk rmlA rmlA galU galU BPSL2769 BPSL2769 gtaB gtaB rfbF rfbF prs prs
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
pgmPhosphoglucomutase; Similar to Neisseria meningitidis phosphoglucomutase Pgm or nmb0790 SWALL:PGMU_NEIMB (SWALL:P40391) (460 aa) fasta scores: E(): 1.2e-98, 56% id in 466 aa and to Ralstonia solanacearum putative phosphomannomutase or phosphoglucomutase protein rsc0691 or rs01596 SWALL:Q8Y1J9 (EMBL:AL646060) (461 aa) fasta scores: E(): 1.6e-123, 68.46% id in 463 aa. (464 aa)    
Predicted Functional Partners:
BPSS1835
Putative LPS biosynthesis mannose-1-phosphate guanylyltransferase; Similar to Salmonella enterica subsp. enterica GDP-mannose pyrophosphorylase ManC SWALL:Q9EXX7 (EMBL:AY012192) (482 aa) fasta scores: E(): 4.4e-76, 48.45% id in 485 aa, and to Escherichia coli O157:H7 mannose-1-phosphate guanylyltransferase ManC or z3195 or ecs2836 SWALL:MANC_ECO57 (SWALL:O85342) (482 aa) fasta scores: E(): 1.2e-75, 48.14% id in 486 aa. Note: Also similar to BPSL0605 ManC (531 aa) fasta scores: E(): 1.2e-105, 63.843% identity in 484 aa overlap; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 0.972
manC-2
Similar to Escherichia coli GDP-mannose pyrophosphorylase ManC SWALL:Q9EXX9 (EMBL:AY012191) (479 aa) fasta scores: E(): 9.4e-105, 56.63% id in 475 aa. Previously sequenced Burkholderia pseudomallei ManC protein SWALL:Q93UK3 (EMBL:AF228583) (475 aa) fasta scores: E(): 5.3e-190, 100% id in 475 aa. Highly similar to Burkholderia mallei putative GDP-mannose pyrophosphorylase ManC SWALL:Q9AI51 (EMBL:AF285636) (475 aa) fasta scores: E(): 1.1e-189, 99.78% id in 475 aa, and to Burkholderia thailandensis putative GDP-mannose pyrophosphorylase ManC SWALL:Q9AI59 (EMBL:AF285634) (476 aa) fasta sco [...]
 
 0.948
manC
Similar to Salmonella typhimurium mannose-1-phosphate guanylyltransferase ManC or CpsB or RfbM SWALL:MANC_SALTY (SWALL:P26340) (480 aa) fasta scores: E(): 2.4e-83, 52.26% id in 486 aa, and to Aeromonas hydrophila putative mannose-1-phosphate guanylyltransferase ManC SWALL:AAM22554 (EMBL:AF343089) (501 aa) fasta scores: E(): 1.2e-88, 47.74% id in 488 aa. Similar to BPSS1835, 63.843% identity (64.644% ungapped) in 484 aa overlap. CDS is extended at the C-terminus in comparison to orthologues and paralogue; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 0.943
glk
Glucokinase; Similar to Escherichia coli, and Escherichia coli O157:H7 glucokinase Glk or b2388 or z3654 or ecs3268 SWALL:GLK_ECOLI (SWALL:P46880) (321 aa) fasta scores: E(): 9e-49, 46.2% id in 316 aa and to Neisseria meningitidis glucokinase Glk or nma1607 or nmb1390 SWALL:GLK_NEIMA (SWALL:Q9JQX3) (328 aa) fasta scores: E(): 4.6e-57, 49.54% id in 327 aa; In the N-terminal section; belongs to the bacterial glucokinase family.
  
 
 0.941
rmlA
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
  
 
 0.939
galU
UTP--glucose-1-phosphate uridylyltransferase; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri UTP--glucose-1-phosphate uridylyltransferase GalU or b1236 or z2012 or ecs1738 SWALL:GALU_ECOLI (SWALL:P25520) (301 aa) fasta scores: E(): 5.6e-51, 54.82% id in 290 aa, and to Burkholderia pseudomallei putative UTP-glucose-1-phosphate uridylyltransferase SWALL:Q9F5N4 (EMBL:AF312223) (295 aa) fasta scores: E(): 2.7e-92, 83.91% id in 286 aa.
   
 0.937
BPSL2769
Putative UTP-glucose-1-phosphate uridylyltransferase; Similar to Xanthomonas campestris UDP-glucose pyrophosphorylase SWALL:P74969 (EMBL:U65532) (324 aa) fasta scores: E(): 5.2e-57, 57.72% id in 272 aa, and to previously sequenced Burkholderia pseudomallei putative UTP-glucose-1-phosphate uridylyltransferase SWALL:Q9F5N4 (EMBL:AF312223) (295 aa) fasta scores: E(): 9.6e-91, 78.15% id in 293 aa, and to Ralstonia solanacearum probable UTP-glucose-1-phosphate uridylyltransferase protein GalU1 or rsc2237 or rs01362 SWALL:Q8XX79 (EMBL:AL646069) (289 aa) fasta scores: E(): 2.3e-90, 77.16% id [...]
   
 0.936
gtaB
Putative UTP-glucose-1-phosphate uridylyltransferase; Similar to Bacillus subtilis UTP--glucose-1-phosphate uridylyltransferase GtaB SWALL:GTAB_BACSU (SWALL:Q05852) (292 aa) fasta scores: E(): 3.2e-52, 49.48% id in 289 aa, and to Burkholderia pseudomallei putative UTP-glucose-1-phosphate uridylyltransferase SWALL:Q9F5N4 (EMBL:AF312223) (295 aa) fasta scores: E(): 5.5e-114, 98.64% id in 295 aa.
   
 0.936
rfbF
Similar to Salmonella typhimurium glucose-1-phosphate cytidylyltransferase RfbF or stm2092 SWALL:RFBF_SALTY (SWALL:P26396) (257 aa) fasta scores: E(): 4e-73, 68.09% id in 257 aa, and to Yersinia enterocolitica DdhA SWALL:Q56860 (EMBL:U46859) (261 aa) fasta scores: E(): 9e-74, 66.14% id in 257 aa.
  
 
 0.935
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 0.933
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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