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rmlB rmlB rmlC rmlC rmlA rmlA rmlD rmlD wbiB wbiB udg2 udg2 wbiC wbiC wcbJ wcbJ wzm wzm wbiE wbiE wzt wzt
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
rmlBdTDP-glucose 4,6-dehydratase; Previously sequenced as Burkholderia pseudomallei putative dTDP-D-glucose 4,6-dehydratase RmlB SWALL:O69116 (EMBL:AF064070) (353 aa) fasta scores: E(): 5.6e-143, 100% id in 353 aa and similar to Xanthomonas campestris dTDP-glucose 4,6-dehydratase RfbB or RmlB or xcc0621 SWALL:RFBB_XANCP (SWALL:P55295) (351 aa) fasta scores: E(): 1.2e-88, 66.56% id in 341 aa; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (353 aa)    
Predicted Functional Partners:
rmlC
dTDP-6-deoxy-D-glucose-3,5 epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
 
 0.999
rmlA
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
 
 
 0.999
rmlD
dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family.
 
 
 0.998
wbiB
Previously sequenced as Burkholderia pseudomallei putative epimerase/dehydratase WbiB SWALL:O69123 (EMBL:AF064070) (363 aa) fasta scores: E(): 1e-138, 100% id in 363 aa. Also similar to Burkholderia mallei putative epimerase/dehydratase WbiB SWALL:Q9AEV2 (EMBL:AY028370) (363 aa) fasta scores: E(): 2.1e-138, 99.72% id in 363 aa and to Rhizobium loti putative sugar nucleotide epimerase/dehydratase mlr7558 SWALL:Q985R8 (EMBL:AP003012) (352 aa) fasta scores: E(): 1.3e-76, 57.71% id in 350 aa.
 
 
0.981
udg2
UDP-glucose 6-dehydrogenase 2; Similar to Pseudomonas aeruginosa UDP-glucose 6-dehydrogenase Udg or Ugd or pa2022 SWALL:UDG_PSEAE (SWALL:O86422) (453 aa) fasta scores: E(): 5.7e-83, 51.97% id in 456 aa, and to Rhizobium meliloti UDP-glucose 6-dehydrogenase RkpK or r01082 or smc02641 SWALL:UDG_RHIME (SWALL:O54068) (437 aa) fasta scores: E(): 2.8e-70, 49.66% id in 453 aa. Note: Also similar to BPSL2511 Udg (467 aa) fasta scores: E(): 1.5e-121, 76.304% identity in 460 aa overlap.
  
  
 0.889
wbiC
Putative glycosyl transferase; Previously sequenced as Burkholderia pseudomallei putative glycosyl transferase WbiC SWALL:O69124 (EMBL:AF064070) (307 aa) fasta scores: E(): 7e-121, 100% id in 307 aa. Also similar to Rhizobium loti putative glycosyl transferase mlr7339 SWALL:Q986I6 (EMBL:AP003011) (296 aa) fasta scores: E(): 5.3e-54, 48.82% id in 297 aa.
 
  
 0.885
wcbJ
Similar to Azorhizobium caulinodans putative capsular polysaccharide biosynthesis protein Oac2 SWALL:Q06936 (EMBL:Z22611) (296 aa) fasta scores: E(): 1.7e-06, 27.13% id in 199 aa. Identical to Burkholderia mallei putative capsular polysaccharide biosynthesis protein WcbJ SWALL:Q9AI39 (EMBL:AF285636) (280 aa) fasta scores: E(): 1.2e-109, 100% id in 280 aa.
 
  
 0.839
wzm
Identical to Burkholderia mallei putative ABC-2 transporter integral membrane component Wzm SWALL:Q9AEV4 (EMBL:AY028370) (277 aa) fasta scores: E(): 3.9e-105, 100% id in 277 aa. Similar to Serratia marcescens putative ABC transporter system integral membrane protein SWALL:O52482 (EMBL:AF038816) (277 aa) fasta scores: E(): 2.5e-58, 57.46% id in 268 aa.
 
   
 0.837
wbiE
Putative glycosyl transferase; Previously sequenced as Burkholderia pseudomallei putative glycosyl transferase WbiE SWALL:O69126 (EMBL:AF064070) (613 aa) fasta scores: E(): 0, 99.51% id in 613 aa.Also similar to Burkholderia mallei putative glycosyl transferase WbiE SWALL:Q9AEV0 (EMBL:AY028370) (613 aa) fasta scores: E(): 0, 99.67% id in 613 aa.
 
  
 0.833
wzt
ABC transporter, ATP-binding component; Previously sequenced as Burkholderia pseudomallei putative ABC-2 transporter hydrophilic component Wzt SWALL:O69121 (EMBL:AF064070) (469 aa) fasta scores: E(): 2.1e-157, 100% id in 469 aa. Also similar to Burkholderia mallei putative ABC-2 transporter hydrophilic component Wzt SWALL:Q9AEV3 (EMBL:AY028370) (469 aa) fasta scores: E(): 1.7e-156, 99.57% id in 469 aa and to Pseudomonas aeruginosa probable ATP-binding component of ABC transporter pa1386 SWALL:Q9I3V8 (EMBL:AE004568) (422 aa) fasta scores: E(): 5.3e-35, 40.04% id in 427 aa.
 
   
 0.831
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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