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pyrB pyrB pyrX pyrX carA carA carB carB pyrR pyrR pyrC pyrC purA purA BPSL1681 BPSL1681 BPSL0682 BPSL0682 asnO asnO BPSS0677 BPSS0677
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
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[Homology]
Score
pyrBSimilar to Ralstonia solanacearum aspartate carbamoyltransferase PyrB or rsc0678 or rs01583 SWALL:PYRB_RALSO (SWALL:Q8Y1L2) (323 aa) fasta scores: E(): 1.7e-105, 88.64% id in 317 aa, and to Pseudomonas aeruginosa aspartate carbamoyltransferase PyrB or pa0402 SWALL:PYRB_PSEAE (SWALL:Q59653) (334 aa) fasta scores: E(): 4e-81, 69.8% id in 308 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (343 aa)    
Predicted Functional Partners:
pyrX
Dihydroorotase-like protein; Similar to Mycobacterium tuberculosis dihydroorotase PyrC or rv1381 or mt1425 or mtcy02b12.15 SWALL:PYRC_MYCTU (SWALL:P71809) (430 aa) fasta scores: E(): 8.6e-48, 39.9% id in 426 aa. Also similar to Ralstonia solanacearum probable dihydroorotase-like protein PyrX or rsc0679 or rs01584 SWALL:Q8Y1L1 (EMBL:AL646060) (425 aa) fasta scores: E(): 1.7e-122, 75.41% id in 423 aa.
 0.999
carA
Carbamoyl-phosphate synthase small chain; Similar to Escherichia coli, and Escherichia coli O157:H7 carbamoyl-phosphate synthase small chain CarA or PyrA or b0032 or z0037 or ecs0035 SWALL:CARA_ECOLI (SWALL:P00907) (382 aa) fasta scores: E(): 4.3e-94, 64.87% id in 373 aa, and to Ralstonia solanacearum carbamoyl-phosphate synthase small chain rsc1519 or rs03785 SWALL:CARA_RALSO (SWALL:Q8XZ85) (378 aa) fasta scores: E(): 6.4e-127, 83.28% id in 377 aa; Belongs to the CarA family.
 
 0.998
carB
Similar to Escherichia coli carbamoyl-phosphate synthase large chain CarB or PyrA or b0033 SWALL:CARB_ECOLI (SWALL:P00968) (1072 aa) fasta scores: E(): 0, 68.93% id in 1088 aa, and to Ralstonia solanacearum carbamoyl-phosphate synthase large chain rsc1521 or rs03783 SWALL:Q8XZ83 (EMBL:AL646065) (1081 aa) fasta scores: E(): 0, 85.82% id in 1086 aa; Belongs to the CarB family.
 
 0.998
pyrR
Bifunctional regulator/uracil phosphoribosyltransferase; Similar to Bacillus caldolyticus PyrR bifunctional protein [includes: pyrimidine operon regulatory protein; uracil phosphoribosyltransferase] SWALL:PYRR_BACCL (SWALL:P41007) (179 aa) fasta scores: E(): 2.1e-14, 41.61% id in 161 aa, and to Pseudomonas aeruginosa PyrR bifunctional protein [includes: pyrimidine operon regulatory protein; uracil phosphoribosyltransferase pyrr or pa0403 SWALL:Q9X6W6 (EMBL:AF148692) (170 aa) fasta scores: E(): 2.7e-21, 47.02% id in 151 aa.
 
 
 0.987
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
   
 
 0.968
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.947
BPSL1681
Similar to Bacillus subtilis allantoinase PucH SWALL:ALN_BACSU (SWALL:O32137) (446 aa) fasta scores: E(): 6.1e-31, 29.27% id in 444 aa, and to Streptomyces coelicolor probable allantoinase sco6247 or scah10.12 or stah10.12 SWALL:ALN_STRCO (SWALL:Q9RKU5) (445 aa) fasta scores: E(): 9.5e-31, 31.62% id in 449 aa.
 
 
 0.936
BPSL0682
Similar to Escherichia coli asparagine synthetase B [glutamine-hydrolyzing] asnB or b0674 SWALL:ASNB_ECOLI (SWALL:P22106) (553 aa) fasta scores: E(): 7.9e-21, 32.63% id in 524 aa, and to Lactococcus lactis asparagine synthetase B asnB or ll0352 SWALL:Q9CIK5 (EMBL:AE006272) (530 aa) fasta scores: E(): 4.7e-30, 30.04% id in 476 aa, and to Caenorhabditis elegans M02d8.4 protein m02d8.4 SWALL:Q21463 (EMBL:U41034) (567 aa) fasta scores: E(): 6e-28, 30.66% id in 525 aa.
  
 
 0.912
asnO
Similar to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 3 AsnO SWALL:ASNO_BACSU (SWALL:O05272) (614 aa) fasta scores: E(): 1.6e-68, 42.01% id in 626 aa, and to Streptomyces aureofaciens asparagine synthase homolog TcsG SWALL:Q9FAR2 (EMBL:AB039379) (609 aa) fasta scores: E(): 2.6e-128, 54.76% id in 619 aa.
  
 
 0.912
BPSS0677
Putative asparagine synthetase; Similar to Burkholderia cepacia genomovar III putative asparagine synthetase SWALL:Q8VP10 (EMBL:AY028431) (656 aa) fasta scores: E(): 6e-206, 74.54% id in 656 aa. N-terminal region is similar to the N-terminal region of Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 2 AsnH SWALL:ASNH_BACSU (SWALL:P42113) (747 aa) fasta scores: E(): 4.6e-23, 27.93% id in 605 aa.
  
 
 0.912
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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