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wcbK wcbK BPSS1835 BPSS1835 wcbL wcbL manC-2 manC-2 manC manC BPSL0618 BPSL0618 BPSS1834 BPSS1834 wcbN wcbN wcbM wcbM gca gca BPSS1689 BPSS1689
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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wcbKPutative GDP sugar epimerase/dehydratase protein; Similar to Aneurinibacillus thermoaerophilus GDP-6-deoxy-D-lyxo-4-hexulose reductase Rmd SWALL:Q9EYP5 (EMBL:AF317224) (309 aa) fasta scores: E(): 4.3e-31, 35.4% id in 322 aa. Identical to Burkholderia mallei putative GDP epimerase/dehydratase WcbK SWALL:Q9AI38 (EMBL:AF285636) (337 aa) fasta scores: E(): 1.2e-132, 100% id in 337 aa. (337 aa)    
Predicted Functional Partners:
BPSS1835
Putative LPS biosynthesis mannose-1-phosphate guanylyltransferase; Similar to Salmonella enterica subsp. enterica GDP-mannose pyrophosphorylase ManC SWALL:Q9EXX7 (EMBL:AY012192) (482 aa) fasta scores: E(): 4.4e-76, 48.45% id in 485 aa, and to Escherichia coli O157:H7 mannose-1-phosphate guanylyltransferase ManC or z3195 or ecs2836 SWALL:MANC_ECO57 (SWALL:O85342) (482 aa) fasta scores: E(): 1.2e-75, 48.14% id in 486 aa. Note: Also similar to BPSL0605 ManC (531 aa) fasta scores: E(): 1.2e-105, 63.843% identity in 484 aa overlap; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.964
wcbL
Putative sugar kinase; Similar to Aneurinibacillus thermoaerophilus D-glycero-d-manno-heptose 7-phosphate kinase GmhB SWALL:Q9AGY8 (EMBL:AF324836) (341 aa) fasta scores: E(): 1.6e-79, 55.84% id in 342 aa. Previously sequenced Burkholderia pseudomallei putative sugar kinase WcbL SWALL:Q93UJ3 (EMBL:AF228583) (346 aa) fasta scores: E(): 5.3e-139, 100% id in 346 aa.
 
   
 0.949
manC-2
Similar to Escherichia coli GDP-mannose pyrophosphorylase ManC SWALL:Q9EXX9 (EMBL:AY012191) (479 aa) fasta scores: E(): 9.4e-105, 56.63% id in 475 aa. Previously sequenced Burkholderia pseudomallei ManC protein SWALL:Q93UK3 (EMBL:AF228583) (475 aa) fasta scores: E(): 5.3e-190, 100% id in 475 aa. Highly similar to Burkholderia mallei putative GDP-mannose pyrophosphorylase ManC SWALL:Q9AI51 (EMBL:AF285636) (475 aa) fasta scores: E(): 1.1e-189, 99.78% id in 475 aa, and to Burkholderia thailandensis putative GDP-mannose pyrophosphorylase ManC SWALL:Q9AI59 (EMBL:AF285634) (476 aa) fasta sco [...]
 
 
 0.938
manC
Similar to Salmonella typhimurium mannose-1-phosphate guanylyltransferase ManC or CpsB or RfbM SWALL:MANC_SALTY (SWALL:P26340) (480 aa) fasta scores: E(): 2.4e-83, 52.26% id in 486 aa, and to Aeromonas hydrophila putative mannose-1-phosphate guanylyltransferase ManC SWALL:AAM22554 (EMBL:AF343089) (501 aa) fasta scores: E(): 1.2e-88, 47.74% id in 488 aa. Similar to BPSS1835, 63.843% identity (64.644% ungapped) in 484 aa overlap. CDS is extended at the C-terminus in comparison to orthologues and paralogue; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.937
BPSL0618
Putative sugar transferase; Similar to Escherichia coli putative colanic biosynthesis UDP-glucose lipid carrier transferase WcaJ SWALL:WCAJ_ECOLI (SWALL:P71241) (464 aa) fasta scores: E(): 9.8e-58, 37.08% id in 480 aa, and to Klebsiella pneumoniae probable capsular polysaccharide biosynthesis glycosyltransferase SWALL:YC14_KLEPN (SWALL:Q48460) (465 aa) fasta scores: E(): 8.3e-54, 35.71% id in 476 aa. Similar to BPSS1834, 50.433% identity (50.873% ungapped) in 462 aa overlap.
 
  
 0.936
BPSS1834
Putative lipopolysaccharide biosynthesis related protein; Similar to Escherichia coli putative colanic biosynthesis UDP-glucose lipid carrier transferase WcaJ or b2047 SWALL:WCAJ_ECOLI (SWALL:P71241) (464 aa) fasta scores: E(): 2.5e-59, 39.65% id in 469 aa, and to Salmonella typhimurium putative undecaprenylphosphate glucosephosphotransferase WcaJ or stm2103 SWALL:Q9F799 (EMBL:AF285085) (464 aa) fasta scores: E(): 2.8e-58, 38.92% id in 465 aa. Note: Also similar to BPSL0618 (473 aa) fasta scores: E(): 3.5e-96, 50.433% identity in 462 aa overlap.
 
  
 0.935
wcbN
Similar to Aneurinibacillus thermoaerophilus D-glycero-d-manno-heptose 1,7-bisphosphate phosphatase GmhC SWALL:Q9AGY5 (EMBL:AF324836) (179 aa) fasta scores: E(): 3.6e-35, 60% id in 155 aa. Identical to Burkholderia mallei WcbN protein SWALL:Q9AI34 (EMBL:AF285636) (189 aa) fasta scores: E(): 9.5e-78, 100% id in 189 aa.
 
   
 0.932
wcbM
Similar to Aneurinibacillus thermoaerophilus D-glycero-d-manno-heptose 1-phosphate guanosyltransferase GmhD SWALL:Q9AGY6 (EMBL:AF324836) (230 aa) fasta scores: E(): 4.6e-29, 39.55% id in 225 aa. Previously sequenced Burkholderia pseudomallei putative capsular polysaccharide biosynthesis protein WcbM SWALL:Q93UJ1 (EMBL:AF228583) (230 aa) fasta scores: E(): 5e-89, 99.56% id in 230 aa.
 
   
 0.932
gca
GCP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
  
  
 
0.927
BPSS1689
Similar to Xylella fastidiosa UDP-glucose 4-epimerase xf0610 SWALL:Q9PFP7 (EMBL:AE003906) (295 aa) fasta scores: E(): 9.9e-53, 53.71% id in 296 aa, and to Xanthomonas campestris UDP-glucose 4-epimerase Rmd or xcc0608 SWALL:AAM39924 (EMBL:AE012159) (312 aa) fasta scores: E(): 1.3e-49, 50.65% id in 304 aa.
  
  
 
0.924
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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