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tyrZ tyrZ pheT pheT metG metG argS argS serS serS proS proS valS valS leuS leuS hisS hisS prfA prfA cysS cysS
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
tyrZtyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (413 aa)    
Predicted Functional Partners:
pheT
Similar to Escherichia coli phenylalanyl-tRNA synthetase beta chain PheT or b1713 SWALL:SYFB_ECOLI (SWALL:P07395) (795 aa) fasta scores: E(): 3.2e-119, 41.84% id in 815 aa, and to Ralstonia solanacearum probable phenylalanyl-tRNA synthetase beta chain protein rsc1582 or rs05825 SWALL:Q8XZ24 (EMBL:AL646065) (809 aa) fasta scores: E(): 0, 67.53% id in 810 aa.
  
  
 0.935
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 
 0.835
argS
Similar to Corynebacterium glutamicum arginyl-tRNA synthetase ArgS SWALL:SYR_CORGL (SWALL:P35868) (550 aa) fasta scores: E(): 1.5e-26, 42.07% id in 599 aa, and to Ralstonia solanacearum probable arginyl-tRNA synthetase rsc0287 or rs03254 SWALL:Q8Y2P8 (EMBL:AL646058) (600 aa) fasta scores: E(): 6.2e-117, 70.18% id in 607 aa.
 
  
 0.806
serS
seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
 
  
 0.794
proS
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
 
  
 0.781
valS
Putative valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
 
  
 0.770
leuS
Similar to Escherichia coli leucyl-tRNA synthetase LeuS or b0642 SWALL:SYL_ECOLI (SWALL:P07813) (860 aa) fasta scores: E(): 6.2e-173, 49.42% id in 872 aa, and to Ralstonia solanacearum probable leucyl-tRNA synthetase protein rsc2744 or rs00110 SWALL:Q8XVT3 (EMBL:AL646071) (877 aa) fasta scores: E(): 0, 73.8% id in 878 aa; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 0.734
hisS
histidyl-tRNA synthetase; Similar to Escherichia coli, and Escherichia coli O157:H7 histidyl-tRNA synthetase HisS or b2514 or z3777 or ecs3376 SWALL:SYH_ECOLI (SWALL:P04804) (423 aa) fasta scores: E(): 1.2e-82, 54.52% id in 420 aa, and to Ralstonia solanacearum probable histidine-tRNA synthetase protein HisS or rsc1216 or rs02790 SWALL:Q8Y029 (EMBL:AL646063) (432 aa) fasta scores: E(): 1e-130, 75.4% id in 435 aa.
  
  
 0.733
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.732
cysS
Similar to Escherichia coli cysteinyl-tRNA synthetase CysS or b0526 SWALL:SYC_ECOLI (SWALL:P21888) (461 aa) fasta scores: E(): 4.5e-95, 55.88% id in 467 aa, and to Ralstonia solanacearum cysteinyl-tRNA synthetase rsc1167 or rs04577 SWALL:SYC_RALSO (SWALL:Q8Y077) (465 aa) fasta scores: E(): 7.8e-137, 74.4% id in 465 aa; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.725
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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