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nrdB nrdB BPSL2992 BPSL2992 BPSS0479 BPSS0479 BPSS2282 BPSS2282 tmk tmk cmk cmk adk adk ndk ndk pykA pykA gmk gmk pyk pyk
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
nrdBRibonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (350 aa)    
Predicted Functional Partners:
BPSL2992
Putative ribonucleoside reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
 0.999
BPSS0479
Putative ribonucleotide reductase protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 0.994
BPSS2282
Similar to Ralstonia solanacearum hypothetical protein rsc0195 or rs00627 SWALL:Q8Y2Y6 (EMBL:AL646058) (617 aa) fasta scores: E(): 5.8e-101, 50.6% id in 581 aa. C-terminus is similar to the N-terminal region of Thermoanaerobacter tengcongensis ribonucleotide reductase alpha subunit tte2336 SWALL:Q8R7R2 (EMBL:AE013176) (691 aa) fasta scores: E(): 7.8e-32, 30% id in 570 aa.
  
 0.994
tmk
Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.932
cmk
Cytidylate kinase; Similar to Escherichia coli, and Escherichia coli O157:H7 cytidylate kinase cmk or mssa or b0910 or z1256 or ecs0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 1.3e-36, 53.91% id in 217 aa, and to Bordetella bronchiseptica cytidylate kinase cmK SWALL:KCY_BORBR (SWALL:Q9RND6) (223 aa) fasta scores: E(): 2.6e-43, 62.26% id in 212 aa.
    
 0.932
adk
Putative adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.930
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.922
pykA
Putative pyruvate kinase II protein; Similar to Pseudomonas hydrogenothermophila pyruvate kinase Pyk SWALL:Q9LBF0 (EMBL:AB042618) (473 aa) fasta scores: E(): 5.5e-91, 58.82% id in 476 aa, and to Ralstonia solanacearum probable pyruvate kinase II protein rsc0572 or rs04893 SWALL:Q8Y1W5 (EMBL:AL646060) (479 aa) fasta scores: E(): 2.9e-131, 78.49% id in 479 aa.
     
 0.914
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.914
pyk
Pyruvate kinase; Similar to Bacillus stearothermophilus pyruvate kinase Pyk SWALL:KPYK_BACST (SWALL:Q02499) (587 aa) fasta scores: E(): 1.7e-60, 41.27% id in 470 aa, and to Pseudomonas aeruginosa pyruvate kinase I PykF or pa1498 SWALL:Q9I3L4 (EMBL:AE004578) (477 aa) fasta scores: E(): 1.5e-83, 55.57% id in 466 aa.
     
 0.914
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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