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proS proS argS argS ileS1 ileS1 ileS2 ileS2 metG metG lysS lysS BPSS0820 BPSS0820 leuS leuS gltX gltX glnS glnS gluQ gluQ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (578 aa)    
Predicted Functional Partners:
argS
Similar to Corynebacterium glutamicum arginyl-tRNA synthetase ArgS SWALL:SYR_CORGL (SWALL:P35868) (550 aa) fasta scores: E(): 1.5e-26, 42.07% id in 599 aa, and to Ralstonia solanacearum probable arginyl-tRNA synthetase rsc0287 or rs03254 SWALL:Q8Y2P8 (EMBL:AL646058) (600 aa) fasta scores: E(): 6.2e-117, 70.18% id in 607 aa.
  
 0.968
ileS1
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
  
 0.967
ileS2
Putative isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
  
 0.967
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 0.961
lysS
lysyl-tRNA synthetase; Similar to Escherichia coli, and Escherichia coli O6 lysyl-tRNA synthetase LysS or HerC or AsuD SWALL:SYK1_ECOLI (SWALL:P13030) (504 aa) fasta scores: E(): 3.9e-116, 57.82% id in 505 aa, and to Ralstonia solanacearum putative lysyl-tRNA synthetase protein rsc1028 or rs04223 SWALL:Q8Y0L5 (EMBL:AL646062) (510 aa) fasta scores: E(): 2.3e-173, 81.96% id in 510 aa; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 0.896
BPSS0820
Putative tRNA synthetase; Similar to Escherichia coli leucyl-tRNA synthetase LeuS SWALL:SYL_ECOLI (SWALL:P07813) (860 aa) fasta scores: E(): 1.1e-34, 30.27% id in 806 aa, and to Thermotoga maritima leucyl-tRNA synthetase leus or tm0168 SWALL:SYL_THEMA (SWALL:Q9WY15) (824 aa) fasta scores: E(): 7.5e-38, 33.33% id in 765 aa. CDS is truncated at the C-terminus in comparison to some orthologues; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 0.895
leuS
Similar to Escherichia coli leucyl-tRNA synthetase LeuS or b0642 SWALL:SYL_ECOLI (SWALL:P07813) (860 aa) fasta scores: E(): 6.2e-173, 49.42% id in 872 aa, and to Ralstonia solanacearum probable leucyl-tRNA synthetase protein rsc2744 or rs00110 SWALL:Q8XVT3 (EMBL:AL646071) (877 aa) fasta scores: E(): 0, 73.8% id in 878 aa; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 0.891
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
  
 0.882
glnS
Similar to Escherichia coli glutaminyl-tRNA synthetase GlnS or b0680 SWALL:SYQ_ECOLI (SWALL:P00962) (553 aa) fasta scores: E(): 9.9e-131, 57.34% id in 558 aa, and to Ralstonia solanacearum glutaminyl-tRNA synthetase rsc0791 or rs05046 SWALL:Q8Y199 (EMBL:AL646061) (580 aa) fasta scores: E(): 1.9e-175, 70.35% id in 570 aa.
  
 0.878
gluQ
Putative glutamyl tRNA synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
  
 0.855
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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