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prfA prfA hemK hemK rpsG rpsG rpmA rpmA rplT rplT rplM rplM rplC rplC rpsL rpsL rpsB rpsB rplQ rplQ rplP rplP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (360 aa)    
Predicted Functional Partners:
hemK
Protein methyltransferase HemK; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
 
 
 0.988
rpsG
30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
  
 
 0.982
rpmA
Similar to Escherichia coli 50S ribosomal protein L27 RpmA or b3185 or z4547 or ecs4064 SWALL:RL27_ECOLI (SWALL:P02427) (84 aa) fasta scores: E(): 7.7e-19, 65.43% id in 81 aa; Belongs to the bacterial ribosomal protein bL27 family.
 
 
 0.981
rplT
50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
 
 
 0.979
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
 
 
 0.978
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
 
 
 0.966
rpsL
30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
  
 
 0.966
rpsB
30S ribosomal protein S2; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 30S ribosomal protein S2 RpsB or b0169 or c0204 or z0180 or ecs0171 SWALL:RS2_ECOLI (SWALL:P02351) (240 aa) fasta scores: E(): 4.9e-51, 56.01% id in 241 aa, and to Ralstonia solanacearum 30S ribosomal protein S2 rsc1404 or rs05288 SWALL:Q8XZJ1 (EMBL:AL646064) (247 aa) fasta scores: E(): 1.8e-79, 86.42% id in 243 aa; Belongs to the universal ribosomal protein uS2 family.
 
 
 0.964
rplQ
Similar to Escherichia coli 50S ribosomal protein L17 RplQ or b3294 or z4664 or ecs4159 SWALL:RL17_ECOLI (SWALL:P02416) (127 aa) fasta scores: E(): 4.4e-31, 71.54% id in 123 aa.
 
 
 0.964
rplP
50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
 
 
 0.962
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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