STRINGSTRING
ahcY ahcY metE metE metH2 metH2 metH1 metH1 BPSL1542 BPSL1542 BPSS0190 BPSS0190 metZ metZ BPSL1978 BPSL1978 BPSL1716 BPSL1716 metK metK BPSS1484 BPSS1484
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (473 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.975
metH2
Similar to Ralstonia solanacearum probable 5-methyltetrahydrofolate--homocysteine methyltransferase rsc0295 or rs03262 SWALL:Q8Y2P0 (EMBL:AL646058) (346 aa) fasta scores: E(): 2.9e-107, 80.29% id in 345 aa, and to the N-terminal region Escherichia coli 5-methyltetrahydrofolate--homocysteine methyltransferase MetH SWALL:METH_ECOLI (SWALL:P13009) (1226 aa) fasta scores: E(): 3.2e-72, 59.07% id in 325 aa. BPSL0385 and BPSL03856 are similar to the N- and C-terminal regions of many 5-methyltetrahydrofolate--homocysteine methyltransferases. In some organisms these two domains are also found [...]
  
 
 0.941
metH1
Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.940
BPSL1542
Similar to Escherichia coli cystathionine beta-lyase MetC or b3008 SWALL:METC_ECOLI (SWALL:P06721) (395 aa) fasta scores: E(): 5.8e-47, 37.84% id in 362 aa, and to Ralstonia solanacearum putative cystathionine beta-lyase rsc1639 or rs04013 SWALL:Q8XYW7 (EMBL:AL646065) (404 aa) fasta scores: E(): 3.2e-94, 64.43% id in 388 aa.
  
 0.922
BPSS0190
Putative AraC-family transcriptional regulator (fragment); Pfam match to entry PF00165 HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 16.0, E-value 0.049.
     
 0.922
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
 0.922
BPSL1978
Putative nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
    
 0.915
BPSL1716
Similar to Rhizobium loti cysteine synthase mll9227 SWALL:Q981U9 (EMBL:AP003015) (351 aa) fasta scores: E(): 4.2e-53, 45.74% id in 341 aa, and to Alcaligenes eutrophus cysteine synthase CysM SWALL:CYSM_ALCEU (SWALL:Q44004) (339 aa) fasta scores: E(): 9.2e-16, 31.35% id in 303 aa.
 
 0.870
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
 
 
 0.850
BPSS1484
Putative membrane protein; Similar to Yersinia pestis hypothetical protein ypo3839 or y0391 SWALL:Q8ZAG3 (EMBL:AJ414159) (405 aa) fasta scores: E(): 1.8e-95, 67.09% id in 392 aa, and to Rhizobium loti hypothetical protein Mll9388 SWALL:Q981G1 (EMBL:AP003016) (408 aa) fasta scores: E(): 5.3e-85, 59.43% id in 392 aa; Belongs to the UPF0261 family.
 
      0.841
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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