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phhA phhA PhhB PhhB tyrB tyrB tyrB1 tyrB1 tyrB2 tyrB2 pheA pheA BPSL3239 BPSL3239 hisC1 hisC1 BPSL1724 BPSL1724 hisC hisC hmgA hmgA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
phhAPhenylalanine-4-hydroxylase; Similar to Chromobacterium violaceum phenylalanine-4-hydroxylase PhhA SWALL:PH4H_CHRVO (SWALL:P30967) (297 aa) fasta scores: E(): 1.1e-70, 62.32% id in 284 aa. (297 aa)    
Predicted Functional Partners:
PhhB
Similar to Gallus gallus pterin-4-alpha-carbinolamine dehydratase PcdB or DcoH SWALL:PHS_CHICK (SWALL:O73930) (103 aa) fasta scores: E(): 9.8e-20, 58.51% id in 94 aa, and to Ralstonia solanacearum putative pterin-4-alpha-carbinolamine dehydratase PhhB or Rsc3356 or Rs02631 SWALL:Q8XU38 (EMBL:AL646074) (101 aa) fasta scores: E(): 2.3e-20, 58.33% id in 96 aa.
 
 0.998
tyrB
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB or b4054 SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 1.3e-80, 54.63% id in 399 aa, and to Pseudomonas aeruginosa aspartate aminotransferase AspC or pa3139 SWALL:AAT_PSEAE (SWALL:P72173) (398 aa) fasta scores: E(): 2.6e-111, 73.86% id in 398 aa. Note: Also similar to BPSS0808 (401 aa) fasta scores: E(): 7.1e-72, 53.149% identity in 397 aa overlap.
  
 
 0.969
tyrB1
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 2.1e-90, 58.43% id in 397 aa, and to Klebsiella pneumoniae tyrosine aminotransferase TyrB SWALL:O85746 (EMBL:AF074934) (397 aa) fasta scores: E(): 2.8e-89, 57.17% id in 397 aa. Similar to BPSS2200, 55.556% identity in 396 aa overlap, and to BPSS0355, 53.149% identity in 397 aa overlap. Note: Also similar to BPSS2200 TyrB2 (405 aa)fasta scores: E(): 4.4e-79, 55.556% identity in 396 aa overlap;. Note: Also similar to BPSS2200 (444 aa) fasta scores: E(): 4.4e-7 [...]
  
 
 0.940
tyrB2
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB or b4054 SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 7.1e-92, 58.69% id in 397 aa, and to Pseudomonas putida aromatic-amino-acid aminotransferase TyrB-2 or pp3590 SWALL:AAN69190 (EMBL:AE016787) (398 aa) fasta scores: E(): 3.5e-91, 58.54% id in 398 aa. Note: Also similar to BPSS0808 TyrB1 (401 aa) fasta scores: E(): 1.1e-74, 55.556% identity in 396 aa overlap.
  
 
 0.940
pheA
Similar to many involved in Phenylalanine biosynthesis: Neisseria gonorrhoeae P-protein [includes: chorismate mutase (EC 5.4.99.5) (cm); prephenate dehydratase (EC 4.2.1.51) (pdt)] PheA SWALL:PHEA_NEIGO (SWALL:Q9ZHY3) (362 aa) fasta scores: E(): 1.8e-64, 50% id in 362 aa, Ralstonia solanacearum probable bifunctional protein: chorismate mutase and prephenate dehydratase PheA or rsc0904 or rs04511 SWALL:Q8Y0Y9 (EMBL:AL646061) (371 aa) fasta scores: E(): 9.6e-85, 61.45% id in 358 aa and to Pseudomonas stutzeri p-protein PheA SWALL:PHEA_PSEST (SWALL:P27603) (365 aa) fasta scores: E(): 3.4e [...]
    
 0.936
BPSL3239
Similar to Pseudomonas sp. 4-hydroxyphenylpyruvate dioxygenase SWALL:HPPD_PSESP (SWALL:P80064) (357 aa) fasta scores: E(): 5.7e-37, 57.89% id in 361 aa.
 
  
 0.931
hisC1
Similar to Lactococcus lactis histidinol-phosphate aminotransferase HisC SWALL:HIS8_LACLA (SWALL:Q02135) (360 aa) fasta scores: E(): 1.3e-55, 46.57% id in 350 aa, and to Rhizobium meliloti histidinol-phosphate aminotransferase 2 r03268 or smc03885 SWALL:HI82_RHIME (SWALL:Q92L21) (351 aa) fasta scores: E(): 2e-76, 61.01% id in 354 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
     
 0.909
BPSL1724
Similar to Anabaena sp. histidinol-phosphate aminotransferase 1 HisC1 or alr2092 SWALL:HI81_ANASP (SWALL:Q8YV89) (353 aa) fasta scores: E(): 3.1e-20, 31.17% id in 324 aa, and to Halobacterium volcanii histidinol-phosphate aminotransferase HisC SWALL:HIS8_HALVO (SWALL:P17736) (361 aa) fasta scores: E(): 7.6e-18, 30.74% id in 322 aa.
     
 0.909
hisC
Similar to Streptomyces coelicolor histidinol-phosphate aminotransferase 1 HisC1 or HisC or SCO2053 or SC4G6.22c SWALL:HI81_STRCO (SWALL:P16246) (369 aa) fasta scores: E(): 9.9e-30, 36.63% id in 363 aa, and to Ralstonia solanacearum histidinol-phosphate aminotransferase 1 HisC1 or Rsc2951 or Rs00135 SWALL:HI81_RALSO (SWALL:Q8XV80) (374 aa) fasta scores: E(): 1.9e-87, 67.13% id in 353 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
     
 0.909
hmgA
Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
 
  
 0.905
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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