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kbl kbl tdh tdh soxA soxA gcvP gcvP glyA glyA glyA-2 glyA-2 BPSL1714 BPSL1714 ltaE ltaE soxB soxB BPSL2759 BPSL2759 soxG soxG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (399 aa)    
Predicted Functional Partners:
tdh
Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family.
 
 
 0.997
soxA
Similar to Corynebacterium sp. sarcosine oxidase alpha subunit SoxA SWALL:SOXA_CORS1 (SWALL:Q46337) (967 aa) fasta scores: E(): 2.3e-145, 46.45% id in 1014 aa, and to Ralstonia solanacearum probable sarcosine oxidase SoxA2 or rsc1103 or rs04054 SWALL:Q8Y0E1 (EMBL:AL646062) (1003 aa) fasta scores: E(): 0, 86.14% id in 1003 aa, and to Pseudomonas aeruginosa sarcosine oxidase alpha subunit SoxA or pa5418 SWALL:Q9HTE6 (EMBL:AE004954) (1005 aa) fasta scores: E(): 1.3e-211, 57.46% id in 1011 aa; Belongs to the GcvT family.
  
 0.946
gcvP
Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.945
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.913
glyA-2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.913
BPSL1714
Similar to Aeromonas jandaei L-allo-threonine aldolase LtaA SWALL:LTAA_AERJA (SWALL:O07051) (338 aa) fasta scores: E(): 4.2e-54, 50.59% id in 334 aa, and to Escherichia coli low-specificity L-threonine aldolase LtaE or b0870 SWALL:LTAE_ECOLI (SWALL:P75823) (333 aa) fasta scores: E(): 6.7e-41, 40.58% id in 340 aa. Note: this CDS is longer in its N-terminal region than most of its database matches.
     
 0.909
ltaE
L-allo-threonine aldolase; Similar to Escherichia coli low-specificity L-threonine aldolase LtaE or b0870 SWALL:LTAE_ECOLI (SWALL:P75823) (333 aa) fasta scores: E(): 1.4e-68, 58.98% id in 334 aa, and to Salmonella typhimurium LT2 L-allo-threonine aldolase LtaA SWALL:Q8ZQF1 (EMBL:AE008737) (333 aa) fasta scores: E(): 1.3e-70, 61.07% id in 334 aa.
     
 0.909
soxB
Similar to Corynebacterium sp. sarcosine oxidase beta subunit SoxB SWALL:SOXB_CORS1 (SWALL:P40875) (405 aa) fasta scores: E(): 1.1e-105, 65.91% id in 399 aa, and to Ralstonia solanacearum probable sarcosine oxidase SoxB1 or rsp0046 or rs06046 SWALL:Q8XTR0 (EMBL:AL646076) (414 aa) fasta scores: E(): 3.8e-157, 95.65% id in 414 aa, and to Ralstonia solanacearum probable sarcosine oxidase SoxB2 or rsc1101 or rs04056 SWALL:Q8Y0E3 (EMBL:AL646062) (414 aa) fasta scores: E(): 1.6e-156, 94.92% id in 414 aa.
    
 0.902
BPSL2759
Putative short-chain dehydrogenase; Similar to Streptomyces clavuligerus clavaldehyde dehydrogenase Cad SWALL:Q9LCV7 (EMBL:U87786) (247 aa) fasta scores: E(): 1.1e-22, 36.66% id in 240 aa, and to Ralstonia solanacearum probable oxidoreductase protein rsc0730 or rs05123 SWALL:Q8Y1G0 (EMBL:AL646060) (262 aa) fasta scores: E(): 9.5e-65, 69.23% id in 247 aa, and to Salmonella typhimurium, and Salmonella typhi hypothetical oxidoreductase YdfG or stm1511 or sty1550 SWALL:YDFG_SALTY (SWALL:P40864) (248 aa) fasta scores: E(): 3.8e-64, 68.42% id in 247 aa; Belongs to the short-chain dehydrogena [...]
    
  0.900
soxG
Similar to Corynebacterium sp. sarcosine oxidase gamma subunit SoxG SWALL:SOXG_CORS1 (SWALL:Q46338) (203 aa) fasta scores: E(): 1.6e-11, 32.98% id in 191 aa, and to Ralstonia solanacearum probable sarcosine oxidase SoxG2 or rsc1104 or rs04053 SWALL:Q8Y0E0 (EMBL:AL646062) (210 aa) fasta scores: E(): 2.8e-62, 75.71% id in 210 aa, and to Ralstonia solanacearum probable sarcosine oxidase SoxG1 or rsp0049 or rs02024 SWALL:Q8XTQ7 (EMBL:AL646076) (210 aa) fasta scores: E(): 2.8e-59, 73.81% id in 210 aa.
     
  0.900
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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