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BPSS0514 BPSS0514 BPSS1955 BPSS1955 acoE acoE BPSL1020 BPSL1020 BPSS1466 BPSS1466 sucD sucD sucC sucC BPSL1380 BPSL1380 BPSS0618 BPSS0618 aceB aceB sdhA sdhA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
BPSS0514acetyl-CoA hydrolase/transferase; Similar to Clostridium kluyveri succinyl-CoA:coenzyme A transferase Cat1 SWALL:CAT1_CLOKL (SWALL:P38946) (538 aa) fasta scores: E(): 2e-97, 51.73% id in 520 aa, and to Xanthomonas campestris coa tranferase xcc3588 SWALL:Q8P4W8 (EMBL:AE012479) (504 aa) fasta scores: E(): 1.2e-133, 68.52% id in 502 aa. Possible alternative translational start sites. (534 aa)    
Predicted Functional Partners:
BPSS1955
Putative phosphate acetyltransferase/enoyl-CoA hydratase fusion protein; N-terminal region similar to Pseudomonas aeruginosa (R)-specific enoyl-CoA hydratase PhaJ1 or pa3302 SWALL:Q9LBK2 (EMBL:AB040025) (156 aa) fasta scores: E(): 1.1e-17, 44.44% id in 153 aa, and C-terminal region to Rhizobium meliloti phosphate acetyltransferase Pta SWALL:PTA_RHIME (SWALL:Q9X448) (316 aa) fasta scores: E(): 5.4e-55, 57.37% id in 305 aa.
  
 
 0.952
acoE
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.940
BPSL1020
Similar to Escherichia coli putative aldehyde dehydrogenase AldH or b1300 SWALL:DHAL_ECOLI (SWALL:P23883) (495 aa) fasta scores: E(): 2.3e-61, 41.12% id in 479 aa, and to Ralstonia solanacearum probable aldehyde dehydrogenase oxidoreductase protein rsc2350 or rs01196 SWALL:Q8XWX0 (EMBL:AL646069) (478 aa) fasta scores: E(): 5.1e-138, 73.31% id in 476 aa.
  
 
 0.932
BPSS1466
Putative aldehyde dehydrogenase family protein; Similar to Streptomyces clavuligerus semialdehyde dehydrogenase Pcd SWALL:O85725 (EMBL:AF073895) (512 aa) fasta scores: E(): 2e-120, 66.05% id in 492 aa, and to Ralstonia solanacearum putative transmembrane aldehyde dehydrogenase oxidoreductase protein rsp1591 or rs02148 SWALL:Q8XPP7 (EMBL:AL646085) (504 aa) fasta scores: E(): 9.4e-134, 69.84% id in 504 aa, and to Rhizobium loti aldehyde dehydrogenase mll2867 SWALL:Q98HH4 (EMBL:AP003000) (504 aa) fasta scores: E(): 4.1e-132, 68.93% id in 499 aa.
  
 
 0.932
sucD
succinyl-CoA ligase alpha-chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 0.929
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 0.928
BPSL1380
Putative acetyl-CoA synthetase; Similar to Bacillus subtilis acetyl-coenzyme A synthetase AcsA SWALL:ACSA_BACSU (SWALL:P39062) (572 aa) fasta scores: E(): 5.7e-54, 34.63% id in 540 aa, and to Rhizobium loti acetyl-CoA synthetase mll6017 SWALL:Q98AG0 (EMBL:AP003008) (562 aa) fasta scores: E(): 8.3e-119, 55.51% id in 553 aa.
  
 0.927
BPSS0618
AMP-binding enzyme; Similar to Ralstonia solanacearum probable acetyl-coenzyme A synthetase rsp0651 or rs05571 SWALL:Q8XS30 (EMBL:AL646080) (567 aa) fasta scores: E(): 2.8e-165, 75.22% id in 561 aa, and to Streptomyces coelicolor putative acetyl-coenzyme A synthetase SCO6195 or SC2G5.16 SWALL:Q9Z5A7 (EMBL:AL939126) (558 aa) fasta scores: E(): 1.1e-118, 58.46% id in 561 aa.
  
 0.927
aceB
Similar to Escherichia coli malate synthase A AceB or Mas or b4014 SWALL:MASY_ECOLI (SWALL:P08997) (533 aa) fasta scores: E(): 1.9e-103, 50.84% id in 533 aa, and to Ralstonia solanacearum probable malate synthase A rsc1363 or rs04645 SWALL:Q8XZN2 (EMBL:AL646064) (529 aa) fasta scores: E(): 1.5e-177, 79.84% id in 531 aa.
   
 
 0.925
sdhA
Succinate dehydrogenase flavoprotein subunit; Similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 succinate dehydrogenase flavoprotein subunit SdhA or b0723 or c0801 or z0877 or ecs0748 SWALL:DHSA_ECOLI (SWALL:P10444) (588 aa) fasta scores: E(): 7.9e-127, 55.46% id in 586 aa, and to Ralstonia solanacearum putative succinate dehydrogenase SdhA or rsc1994 or rs03562 SWALL:Q8XXW9 (EMBL:AL646067) (592 aa) fasta scores: E(): 6.1e-201, 85.3% id in 592 aa; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
   
 
 0.920
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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