STRINGSTRING
BPSS0913 BPSS0913 metE metE metH2 metH2 BPSL1716 BPSL1716 metH1 metH1 metG metG metK metK tyrB tyrB tyrB1 tyrB1 tyrB2 tyrB2 trxB trxB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BPSS0913Similar to Escherichia coli cystathionine gamma-synthase MetB SWALL:METB_ECOLI (SWALL:P00935) (386 aa) fasta scores: E(): 1.1e-28, 37.37% id in 396 aa, and to Brucella suis putative methionine-gamma-lyase br1965 SWALL:AAN30856 (EMBL:AE014486) (427 aa) fasta scores: E(): 2e-93, 59.61% id in 411 aa. (433 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.957
metH2
Similar to Ralstonia solanacearum probable 5-methyltetrahydrofolate--homocysteine methyltransferase rsc0295 or rs03262 SWALL:Q8Y2P0 (EMBL:AL646058) (346 aa) fasta scores: E(): 2.9e-107, 80.29% id in 345 aa, and to the N-terminal region Escherichia coli 5-methyltetrahydrofolate--homocysteine methyltransferase MetH SWALL:METH_ECOLI (SWALL:P13009) (1226 aa) fasta scores: E(): 3.2e-72, 59.07% id in 325 aa. BPSL0385 and BPSL03856 are similar to the N- and C-terminal regions of many 5-methyltetrahydrofolate--homocysteine methyltransferases. In some organisms these two domains are also found [...]
  
 
 0.947
BPSL1716
Similar to Rhizobium loti cysteine synthase mll9227 SWALL:Q981U9 (EMBL:AP003015) (351 aa) fasta scores: E(): 4.2e-53, 45.74% id in 341 aa, and to Alcaligenes eutrophus cysteine synthase CysM SWALL:CYSM_ALCEU (SWALL:Q44004) (339 aa) fasta scores: E(): 9.2e-16, 31.35% id in 303 aa.
 
 0.944
metH1
Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.927
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.927
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
   
 0.924
tyrB
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB or b4054 SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 1.3e-80, 54.63% id in 399 aa, and to Pseudomonas aeruginosa aspartate aminotransferase AspC or pa3139 SWALL:AAT_PSEAE (SWALL:P72173) (398 aa) fasta scores: E(): 2.6e-111, 73.86% id in 398 aa. Note: Also similar to BPSS0808 (401 aa) fasta scores: E(): 7.1e-72, 53.149% identity in 397 aa overlap.
   
 
 0.909
tyrB1
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 2.1e-90, 58.43% id in 397 aa, and to Klebsiella pneumoniae tyrosine aminotransferase TyrB SWALL:O85746 (EMBL:AF074934) (397 aa) fasta scores: E(): 2.8e-89, 57.17% id in 397 aa. Similar to BPSS2200, 55.556% identity in 396 aa overlap, and to BPSS0355, 53.149% identity in 397 aa overlap. Note: Also similar to BPSS2200 TyrB2 (405 aa)fasta scores: E(): 4.4e-79, 55.556% identity in 396 aa overlap;. Note: Also similar to BPSS2200 (444 aa) fasta scores: E(): 4.4e-7 [...]
   
 
 0.909
tyrB2
Similar to Escherichia coli aromatic-amino-acid aminotransferase TyrB or b4054 SWALL:TYRB_ECOLI (SWALL:P04693) (397 aa) fasta scores: E(): 7.1e-92, 58.69% id in 397 aa, and to Pseudomonas putida aromatic-amino-acid aminotransferase TyrB-2 or pp3590 SWALL:AAN69190 (EMBL:AE016787) (398 aa) fasta scores: E(): 3.5e-91, 58.54% id in 398 aa. Note: Also similar to BPSS0808 TyrB1 (401 aa) fasta scores: E(): 1.1e-74, 55.556% identity in 396 aa overlap.
   
 
 0.909
trxB
Thioredoxin reductase; Similar to Escherichia coli, and Escherichia coli O157:H7 thioredoxin reductase TrxB or b0888 or z1232 or ecs0973 SWALL:TRXB_ECOLI (SWALL:P09625) (320 aa) fasta scores: E(): 4.2e-82, 67.39% id in 319 aa, and to Vibrio cholerae thioredoxin reductase TrxB or vc1182 SWALL:TRXB_VIBCH (SWALL:Q9KSS4) (318 aa) fasta scores: E(): 4.3e-85, 69.52% id in 315 aa.
   
 
 0.907
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.