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folE-2 folE-2 BPSL0179 BPSL0179 folE2 folE2 ribB-2 ribB-2 folE folE ribA ribA RibA RibA BPSL2822 BPSL2822 NtpA NtpA moaA moaA moaA-2 moaA-2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
folE-2Similar to Bacillus subtilis GTP cyclohydrolase I FolE or MtrA SWALL:GCH1_BACSU (SWALL:P19465) (190 aa) fasta scores: E(): 2.9e-19, 33.33% id in 189 aa, and to Ralstonia solanacearum GTP cyclohydrolase I FolE or rsc1387 or rs04670 SWALL:Q8XZK8 (EMBL:AL646064) (209 aa) fasta scores: E(): 7.5e-67, 84.12% id in 189 aa. (210 aa)    
Predicted Functional Partners:
BPSL0179
6-pyruvoyl tetrahydropterin synthase; Similar to Ralstonia solanacearum putative 6-pyruvoyl tetrahydrobiopterin synthase protein rsc1450 or rs03857 SWALL:Q8XZF1 (EMBL:AL646064) (158 aa) fasta scores: E(): 1.1e-34, 65.27% id in 144 aa, and to Neisseria meningitidis hypothetical protein NMA0704 SWALL:Q9JVT6 (EMBL:AL162754) (140 aa) fasta scores: E(): 3e-13, 39.18% id in 148 aa.
 
 
 0.974
folE2
Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate.
     
 0.947
ribB-2
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
  
 
 0.936
folE
Similar to Bacillus subtilis GTP cyclohydrolase I FolE or MtrA SWALL:GCH1_BACSU (SWALL:P19465) (190 aa) fasta scores: E(): 1.6e-29, 47.64% id in 170 aa, and to Xanthomonas campestris GTP cyclohydrolase I xcc4166 SWALL:GCH1_XANCP (SWALL:Q8P3B0) (200 aa) fasta scores: E(): 5.6e-45, 65.69% id in 172 aa. Note: This CDS has a possible alternative start codon 156 residues upstream.
  
  
 
0.922
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.
   
 
 0.910
RibA
Similar to Photobacterium phosphoreum GTP cyclohydrolase II RibA SWALL:GCH2_PHOPO (SWALL:P51618) (200 aa) fasta scores: E(): 5.1e-37, 52.47% id in 202 aa, and to Pseudomonas glumae GTP cyclohydrolase II toxB SWALL:Q8RS38 (EMBL:AB040403) (212 aa) fasta scores: E(): 3.4e-64, 77.22% id in 202 aa, and to Vibrio cholerae GTP cyclohydrolase II vc1263 SWALL:Q9KSJ3 (EMBL:AE004205) (216 aa) fasta scores: E(): 1e-41, 54.8% id in 208 aa. Possible translational start site after codon 9.
   
 
 0.910
BPSL2822
Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK or b0142 SWALL:HPPK_ECOLI (SWALL:P26281) (158 aa) fasta scores: E(): 1.7e-13, 39.35% id in 155 aa, and to Ralstonia solanacearum probable 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase protein FolK or rsc2628 or rs00932 SWALL:Q8XW47 (EMBL:AL646071) (169 aa) fasta scores: E(): 2e-41, 62.13% id in 169 aa, and to Bacillus halodurans 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK or bh0095 SW [...]
 
  
 0.909
NtpA
Similar to Escherichia coli dATP pyrophosphohydrolase NudB or NtpA SWALL:NUDB_ECOLI (SWALL:P24236) (150 aa) fasta scores: E(): 8.2e-16, 44.82% id in 145 aa, and to Ralstonia solanacearum probable datp pyrophosphohydrolase protein rsc0468 or rs04429 SWALL:Q8Y268 (EMBL:AL646059) (162 aa) fasta scores: E(): 8.4e-36, 64.55% id in 158 aa.
    
  0.907
moaA
Putative molybdenum cofactor biosynthesis-related protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
  0.903
moaA-2
Putative molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
  0.903
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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