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bopA bopA BPSL0498 BPSL0498 bicP bicP bipD bipD bopE bopE bipB bipB bsaZ bsaZ bsaQ bsaQ BPSS1522 BPSS1522 BPSS0180 BPSS0180 bipC bipC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
bopAPutative intercellular spread protein; Plays a role in mediating bacterial evasion from the host autophagic pathway; Belongs to the BopA/IcsB family. (512 aa)    
Predicted Functional Partners:
BPSL0498
Similar to Pseudomonas aeruginosa probable phosphotransferase protein pa3760 SWALL:Q9HXN5 (EMBL:AE004794) (842 aa) fasta scores: E(): 8e-102, 49.53% id in 860 aa. C-terminus is similar to the C-terminal region of Rhodobacter capsulatus multiphosphoryl transfer protein frub(hi) SWALL:PTF1_RHOCA (SWALL:P23388) (827 aa) fasta scores: E(): 2.7e-78, 40.73% id in 739 aa; Belongs to the PEP-utilizing enzyme family.
   
 
 0.825
bicP
Putative chaperone; Similar to Salmonella typhimurium SicP SWALL:O85300 (EMBL:AF060857) (116 aa) fasta scores: E(): 7.2e-06, 25.89% id in 112 aa, and to Escherichia coli O111:H- Tir chaperone CesT SWALL:CEST_ECO11 (SWALL:O30999) (156 aa) fasta scores: E(): 0.38, 26.11% id in 134 aa.
     
 0.730
bipD
Putative membrane antigen; Required for invasion of epithelial cells, as well as for survival within host cells, escape from endocytic vesicles and subsequent actin-tail formation. Probably regulates the secretion of effectors BipB and BipC and their final integration into the target cell membrane; Belongs to the invasin protein D family.
      
 0.686
bopE
Putative G-nucleotide exchange factor; Activator for both CDC42 and RAC1 by directly interacting with these Rho GTPases and acting as a guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, thus promoting bacterial entry into non-phagocytic cells.
      
 0.685
bipB
Putative cell invasion protein; Plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercellular spreading of bacteria and in the induction of apoptosis in macrophages. May act in concert with other effector proteins to induce fusion of host cell membranes.
      
 0.579
bsaZ
Surface presentation of antigens protein; Part of the bsa type III secretion system, is involved in the intracellular replication of invading bacteria inside the host cell. Probably necessary for the lysis of the vacuole membrane and escape into the host cell cytoplasm.
      
 0.579
bsaQ
Type III secretion system protein; Similar to Salmonella typhimurium, and Salmonella typhi invasion protein InvA or stm2896 or sty3019 SWALL:INVA_SALTY (SWALL:P35657) (685 aa) fasta scores: E(): 7.7e-135, 56.05% id in 694 aa, and to Shigella flexneri, and Shigella sonnei MxiA protein or VirH or cp0147 SWALL:MXIA_SHIFL (SWALL:P35533) (686 aa) fasta scores: E(): 5.3e-133, 55.57% id in 691 aa.
   
  
 0.508
BPSS1522
Similar to Pseudomonas viridiflava response regulator GacA or RepB SWALL:GACA_PSEVI (SWALL:P95582) (214 aa) fasta scores: E(): 3.6e-17, 35.21% id in 213 aa, and to Yersinia pestis putative two-component response regulator ypo0255 or y0512 SWALL:Q8ZJ69 (EMBL:AJ414141) (210 aa) fasta scores: E(): 9e-22, 40.58% id in 207 aa.
     
 0.504
BPSS0180
Conserved hypothetical protein; Similar to Salmonella typhimurium, and Salmonella enterica subsp. enterica serovar Typhimurium putative cytoplasmic protein stm0266 or SciA SWALL:Q93IT5 (EMBL:AE008707) (351 aa) fasta scores: E(): 1.7e-34, 45.33% id in 364 aa, and to Yersinia pestis hypothetical protein ypo2949 SWALL:Q8ZCN2 (EMBL:AJ414154) (393 aa) fasta scores: E(): 5.7e-20, 30.53% id in 393 aa. Note: Also similar to BPSS0110 (357 aa) fasta scores: E(): 1.3e-23, 44.101% identity in 356 aa overlap.
      
 0.499
bipC
Putative cell invasion protein; Weakly similar to Bordetella bronchiseptica outer protein D BopD SWALL:Q9REZ6 (EMBL:AF207788) (313 aa) fasta scores: E(): 1.4, 25.7% id in 284 aa, and to Salmonella typhi SipC protein or sty3007 SWALL:Q56135 (EMBL:X82670) (409 aa) fasta scores: E(): 0.0039, 24.21% id in 285 aa; Belongs to the invasin protein C family.
      
 0.499
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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