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bipB bipB bipD bipD bipC bipC bopE bopE bicA bicA BPSS1547 BPSS1547 bsaR bsaR bsaZ bsaZ bsaP bsaP bsaQ bsaQ BPSS1548 BPSS1548
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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bipBPutative cell invasion protein; Plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercellular spreading of bacteria and in the induction of apoptosis in macrophages. May act in concert with other effector proteins to induce fusion of host cell membranes. (620 aa)    
Predicted Functional Partners:
bipD
Putative membrane antigen; Required for invasion of epithelial cells, as well as for survival within host cells, escape from endocytic vesicles and subsequent actin-tail formation. Probably regulates the secretion of effectors BipB and BipC and their final integration into the target cell membrane; Belongs to the invasin protein D family.
  
  
 0.988
bipC
Putative cell invasion protein; Weakly similar to Bordetella bronchiseptica outer protein D BopD SWALL:Q9REZ6 (EMBL:AF207788) (313 aa) fasta scores: E(): 1.4, 25.7% id in 284 aa, and to Salmonella typhi SipC protein or sty3007 SWALL:Q56135 (EMBL:X82670) (409 aa) fasta scores: E(): 0.0039, 24.21% id in 285 aa; Belongs to the invasin protein C family.
     
 0.906
bopE
Putative G-nucleotide exchange factor; Activator for both CDC42 and RAC1 by directly interacting with these Rho GTPases and acting as a guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, thus promoting bacterial entry into non-phagocytic cells.
   
  
 0.877
bicA
Surface presentation of antigens protein; Similar to Salmonella typhimurium, Salmonella typhi, and Salmonella dublin surface presentation of antigens protein SpaT or SicA or stm2886 or sty3009 SWALL:SPAT_SALTY (SWALL:P40703) (165 aa) fasta scores: E(): 4.2e-37, 61.9% id in 147 aa, and to Shigella flexneri, and Shigella dysenteriae IppI or IpgC or cp0129 SWALL:IPPI_SHIFL (SWALL:P18008) (155 aa) fasta scores: E(): 2.4e-33, 50.32% id in 153 aa.
  
  
 0.843
BPSS1547
Type III secretion system protein; Similar to Salmonella typhimurium PrgH protein or stm2874 SWALL:PRGH_SALTY (SWALL:P41783) (392 aa) fasta scores: E(): 9.1e-12, 23.74% id in 417 aa, and to Salmonella typhi pathogenicity 1 island effector protein PrgH or sty2995 SWALL:Q8Z499 (EMBL:AL627276) (392 aa) fasta scores: E(): 7e-12, 24.46% id in 417 aa.
  
  
 0.840
bsaR
Similar to Salmonella typhimurium, and Salmonella typhi surface presentation of antigens protein SpaK or InvB or stm2895 or sty3018 SWALL:SPAK_SALTY (SWALL:P39443) (135 aa) fasta scores: E(): 4e-06, 27.61% id in 134 aa, and to Shigella sonnei surface presentation of antigens protein spak spak or spa15 SWALL:SPAK_SHISO (SWALL:Q55296) (133 aa) fasta scores: E(): 1.9e-05, 26.51% id in 132 aa.
  
  
 0.803
bsaZ
Surface presentation of antigens protein; Part of the bsa type III secretion system, is involved in the intracellular replication of invading bacteria inside the host cell. Probably necessary for the lysis of the vacuole membrane and escape into the host cell cytoplasm.
  
  
 0.763
bsaP
Type III secretion system protein; Similar to Salmonella typhimurium invasion protein InvE or stm2897 SWALL:INVE_SALTY (SWALL:P35671) (372 aa) fasta scores: E(): 3.8e-24, 33.81% id in 346 aa.
  
  
 0.762
bsaQ
Type III secretion system protein; Similar to Salmonella typhimurium, and Salmonella typhi invasion protein InvA or stm2896 or sty3019 SWALL:INVA_SALTY (SWALL:P35657) (685 aa) fasta scores: E(): 7.7e-135, 56.05% id in 694 aa, and to Shigella flexneri, and Shigella sonnei MxiA protein or VirH or cp0147 SWALL:MXIA_SHIFL (SWALL:P35533) (686 aa) fasta scores: E(): 5.3e-133, 55.57% id in 691 aa.
  
  
 0.714
BPSS1548
Type III secretion system protein; Similar to Salmonella typhimurium PrgI protein or stm2873 SWALL:PRGI_SALTY (SWALL:P41784) (80 aa) fasta scores: E(): 4.2e-12, 55.26% id in 76 aa, and to Shigella flexneri, and Shigella sonnei MxiH protein or cp0137 SWALL:MXIH_SHIFL (SWALL:Q06079) (83 aa) fasta scores: E(): 3.1e-10, 49.35% id in 77 aa.
  
  
 0.633
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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