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gca gca BPSS1689 BPSS1689 BPSS1835 BPSS1835 manC-2 manC-2 manC manC BPSS0422 BPSS0422 BPSL0618 BPSL0618 wcbK wcbK BPSS1834 BPSS1834 BPSS1978 BPSS1978 BPSS1687 BPSS1687
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
gcaGCP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (347 aa)    
Predicted Functional Partners:
BPSS1689
Similar to Xylella fastidiosa UDP-glucose 4-epimerase xf0610 SWALL:Q9PFP7 (EMBL:AE003906) (295 aa) fasta scores: E(): 9.9e-53, 53.71% id in 296 aa, and to Xanthomonas campestris UDP-glucose 4-epimerase Rmd or xcc0608 SWALL:AAM39924 (EMBL:AE012159) (312 aa) fasta scores: E(): 1.3e-49, 50.65% id in 304 aa.
 
  
 
0.982
BPSS1835
Putative LPS biosynthesis mannose-1-phosphate guanylyltransferase; Similar to Salmonella enterica subsp. enterica GDP-mannose pyrophosphorylase ManC SWALL:Q9EXX7 (EMBL:AY012192) (482 aa) fasta scores: E(): 4.4e-76, 48.45% id in 485 aa, and to Escherichia coli O157:H7 mannose-1-phosphate guanylyltransferase ManC or z3195 or ecs2836 SWALL:MANC_ECO57 (SWALL:O85342) (482 aa) fasta scores: E(): 1.2e-75, 48.14% id in 486 aa. Note: Also similar to BPSL0605 ManC (531 aa) fasta scores: E(): 1.2e-105, 63.843% identity in 484 aa overlap; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.971
manC-2
Similar to Escherichia coli GDP-mannose pyrophosphorylase ManC SWALL:Q9EXX9 (EMBL:AY012191) (479 aa) fasta scores: E(): 9.4e-105, 56.63% id in 475 aa. Previously sequenced Burkholderia pseudomallei ManC protein SWALL:Q93UK3 (EMBL:AF228583) (475 aa) fasta scores: E(): 5.3e-190, 100% id in 475 aa. Highly similar to Burkholderia mallei putative GDP-mannose pyrophosphorylase ManC SWALL:Q9AI51 (EMBL:AF285636) (475 aa) fasta scores: E(): 1.1e-189, 99.78% id in 475 aa, and to Burkholderia thailandensis putative GDP-mannose pyrophosphorylase ManC SWALL:Q9AI59 (EMBL:AF285634) (476 aa) fasta sco [...]
 
 
 0.950
manC
Similar to Salmonella typhimurium mannose-1-phosphate guanylyltransferase ManC or CpsB or RfbM SWALL:MANC_SALTY (SWALL:P26340) (480 aa) fasta scores: E(): 2.4e-83, 52.26% id in 486 aa, and to Aeromonas hydrophila putative mannose-1-phosphate guanylyltransferase ManC SWALL:AAM22554 (EMBL:AF343089) (501 aa) fasta scores: E(): 1.2e-88, 47.74% id in 488 aa. Similar to BPSS1835, 63.843% identity (64.644% ungapped) in 484 aa overlap. CDS is extended at the C-terminus in comparison to orthologues and paralogue; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.949
BPSS0422
Putative aminotransferase; C-terminal region similar to Escherichia coli, and Escherichia coli O157:H7 perosamine synthetase Per or RfbE or z3200 or ecs2841 SWALL:O07849 (EMBL:AF061251) (366 aa) fasta scores: E(): 3.5e-50, 38.76% id in 356 aa and N-terminal region similar to Agrobacterium tumefaciens acetyltransferase atu2080 or agr_c_3768 SWALL:Q8UDP1 (EMBL:Q8UDP1) (177 aa) blastp scores: Score = 39.9 bits (91), Expect = 0.14 Identities = 46/165 (27%), Positives = 70/165 (41%), Gaps = 18/165 (10%); Belongs to the DegT/DnrJ/EryC1 family.
    
 0.947
BPSL0618
Putative sugar transferase; Similar to Escherichia coli putative colanic biosynthesis UDP-glucose lipid carrier transferase WcaJ SWALL:WCAJ_ECOLI (SWALL:P71241) (464 aa) fasta scores: E(): 9.8e-58, 37.08% id in 480 aa, and to Klebsiella pneumoniae probable capsular polysaccharide biosynthesis glycosyltransferase SWALL:YC14_KLEPN (SWALL:Q48460) (465 aa) fasta scores: E(): 8.3e-54, 35.71% id in 476 aa. Similar to BPSS1834, 50.433% identity (50.873% ungapped) in 462 aa overlap.
 
  
 0.928
wcbK
Putative GDP sugar epimerase/dehydratase protein; Similar to Aneurinibacillus thermoaerophilus GDP-6-deoxy-D-lyxo-4-hexulose reductase Rmd SWALL:Q9EYP5 (EMBL:AF317224) (309 aa) fasta scores: E(): 4.3e-31, 35.4% id in 322 aa. Identical to Burkholderia mallei putative GDP epimerase/dehydratase WcbK SWALL:Q9AI38 (EMBL:AF285636) (337 aa) fasta scores: E(): 1.2e-132, 100% id in 337 aa.
  
  
 
0.927
BPSS1834
Putative lipopolysaccharide biosynthesis related protein; Similar to Escherichia coli putative colanic biosynthesis UDP-glucose lipid carrier transferase WcaJ or b2047 SWALL:WCAJ_ECOLI (SWALL:P71241) (464 aa) fasta scores: E(): 2.5e-59, 39.65% id in 469 aa, and to Salmonella typhimurium putative undecaprenylphosphate glucosephosphotransferase WcaJ or stm2103 SWALL:Q9F799 (EMBL:AF285085) (464 aa) fasta scores: E(): 2.8e-58, 38.92% id in 465 aa. Note: Also similar to BPSL0618 (473 aa) fasta scores: E(): 3.5e-96, 50.433% identity in 462 aa overlap.
 
  
 0.927
BPSS1978
Similar to Ralstonia solanacearum putative tyrosine-protein kinase EpsB SWALL:EPB2_RALSO (SWALL:Q45409) (750 aa) fasta scores: E(): 3.4e-36, 30.28% id in 733 aa, and to Escherichia coli O157:H7 tyrosine-protein kinase Etk or z1398 or ecs1137 SWALL:ETK_ECO57 (SWALL:Q8XC28) (726 aa) fasta scores: E(): 9.6e-36, 28.78% id in 747 aa.
 
  
 0.675
BPSS1687
Putative membrane protein; Similar to Rhizobium loti hypothetical protein mlr1941 SWALL:Q98JH3 (EMBL:AP002998) (388 aa) fasta scores: E(): 3.8e-18, 35.77% id in 355 aa, and to Corynebacterium glutamicum predicted acyltransferases cgl2858 SWALL:BAC00251 (EMBL:AP005283) (356 aa) fasta scores: E(): 1.2e-11, 29.73% id in 380 aa.
     
 0.669
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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