node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DVU_3121 | gcvH | DVU_3121 | DVU_1426 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.912 |
DVU_3121 | gcvPA | DVU_3121 | DVU_1425 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. N-terminal subunit subfamily. | 0.900 |
DVU_3121 | gcvPB | DVU_3121 | DVU_1424 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | Glycine cleavage system P protein, subunit 2; Identified by similarity to SP:P54377; Belongs to the GcvP family. | 0.912 |
DVU_3121 | gcvT | DVU_3121 | DVU_1684 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.932 |
DVU_3121 | glyA | DVU_3121 | DVU_1203 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the SHMT family. | 0.922 |
DVU_3121 | lpdA | DVU_3121 | DVU_1423 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by similarity to SP:O34324; match to protein family HMM PF00070; match to protein family HMM PF02852. | 0.901 |
DVU_3121 | ltaE | DVU_3121 | DVU_1878 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | Threonine aldolase, low-specificity; Identified by similarity to SP:O50584. | 0.914 |
DVU_3121 | putA | DVU_3121 | DVU_3319 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | 0.449 |
DVU_3121 | sucCD | DVU_3121 | DVU_2137 | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | succinyl-CoA synthase, beta/alpha subunits; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.515 |
gcvH | DVU_3121 | DVU_1426 | DVU_3121 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | 0.912 |
gcvH | gcvPA | DVU_1426 | DVU_1425 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. N-terminal subunit subfamily. | 0.999 |
gcvH | gcvPB | DVU_1426 | DVU_1424 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P protein, subunit 2; Identified by similarity to SP:P54377; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | DVU_1426 | DVU_1684 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.999 |
gcvH | glyA | DVU_1426 | DVU_1203 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the SHMT family. | 0.990 |
gcvH | lpdA | DVU_1426 | DVU_1423 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase; Identified by similarity to SP:O34324; match to protein family HMM PF00070; match to protein family HMM PF02852. | 0.995 |
gcvH | purQ | DVU_1426 | DVU_1622 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Phosphoribosylformylglycinamidine synthase I. | 0.825 |
gcvH | putA | DVU_1426 | DVU_3319 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. | 0.901 |
gcvH | sucCD | DVU_1426 | DVU_2137 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | succinyl-CoA synthase, beta/alpha subunits; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.542 |
gcvPA | DVU_3121 | DVU_1425 | DVU_3121 | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. N-terminal subunit subfamily. | Aminotransferase, class V; Identified by match to protein family HMM PF00266. | 0.900 |
gcvPA | gcvH | DVU_1425 | DVU_1426 | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. N-terminal subunit subfamily. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |