node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DVU_0734 | DVU_1463 | DVU_0734 | DVU_1463 | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | 0.999 |
DVU_0734 | DVU_3057 | DVU_0734 | DVU_3057 | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.617 |
DVU_0734 | hemA | DVU_0734 | DVU_1461 | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.954 |
DVU_0734 | hemB | DVU_0734 | DVU_0856 | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. | 0.994 |
DVU_0734 | hemC | DVU_0734 | DVU_1890 | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
DVU_0734 | hemL | DVU_0734 | DVU_3168 | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P30949; match to protein family HMM PF00202; match to protein family HMM TIGR00713; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.874 |
DVU_0734 | nadE | DVU_0734 | DVU_1610 | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | Glutamine-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.610 |
DVU_1463 | DVU_0734 | DVU_1463 | DVU_0734 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | 0.999 |
DVU_1463 | hemA | DVU_1463 | DVU_1461 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.742 |
DVU_1463 | hemB | DVU_1463 | DVU_0856 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. | 0.477 |
DVU_1463 | hemC | DVU_1463 | DVU_1890 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.940 |
DVU_1463 | hemL | DVU_1463 | DVU_3168 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P30949; match to protein family HMM PF00202; match to protein family HMM TIGR00713; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.847 |
DVU_3057 | DVU_0734 | DVU_3057 | DVU_0734 | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | 0.617 |
DVU_3057 | hemA | DVU_3057 | DVU_1461 | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.471 |
DVU_3057 | hemB | DVU_3057 | DVU_0856 | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. | 0.466 |
DVU_3057 | hemC | DVU_3057 | DVU_1890 | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.573 |
DVU_3057 | hemL | DVU_3057 | DVU_3168 | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P30949; match to protein family HMM PF00202; match to protein family HMM TIGR00713; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.461 |
hemA | DVU_0734 | DVU_1461 | DVU_0734 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. | 0.954 |
hemA | DVU_1463 | DVU_1461 | DVU_1463 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | 0.742 |
hemA | DVU_3057 | DVU_1461 | DVU_3057 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.471 |